Protein Alignment Hr3 and Rorb

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_666207.3
• Gene: Rorb / 225998
• MGIID: 1343464
• Length: 470
• Species: Mus musculus
• Alignment Length: 469
• Identity: 187/469 - (39%)
• Similarity: 263/469 - (56%)
• Gaps: 49/469 - (10%)

  Fly   429 TAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCR 493
            |||||:||||:|||||||:||||||||||||||||||.:..:|.|||.:.|::||.||||||:||
Mouse    13 TAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCR 77

  Fly   494 LQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQ-----SDAAPDSSVYDTQTPSSSD 553
            |||||.||||||||||||||||||:.:..||:.|:.:::.|     .:|...:.||.:   |.|:
Mouse    78 LQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSS---SISN 139

  Fly   554 QLHHNNYNSGG-YSNNEV-------GYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIID 610
            .|.:.|..:|| |:|..|       ||     ||.........|..:....:.....||   |.|
Mouse   140 GLSNLNTETGGTYANGHVIDLPKSEGY-----YSIDSGQPSPDQSGLDMTGIKQIKQEP---IYD 196

  Fly   611 ----PEFISHA---DGDIN--------DVLIKTLAEAHANT-NTKLEAVHDMFRKQPDVSRILYY 659
                |...:::   :|.:.        |.:.:.:.::|..| ...:|.:|.:..:......|..|
Mouse   197 LTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAY 261

  Fly   660 KNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQ 724
            ::..:|.||..||.::|..||.::||||.|.|||.|.|:|||||||:|..|:.:|||.|..:...
Mouse   262 QSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLN 326

  Fly   725 NAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGN 789
            |.||:.......:.|....|::  ||:..|..||::..|:|||.|:||:.|.||:.|:|..:...
Mouse   327 NTVLFEGKYGGMQMFKALGSDD--LVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEP 389

  Fly   790 TEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVV- 853
            .::|:|......|::..::.||.    |...|..|:..||....:..||.|.|..||..||::|
Mouse   390 RKVQKLQEKIYFALQHVIQKNHL----DDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVN 450

  Fly   854 --FPALYKELFSID 865
              ||.||||||:.|
Mouse   451 TLFPPLYKELFNPD 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	71/93 (76%)
		NR_LBD	620..862	CDD:472173	85/253 (34%)
Rorb	NP_666207.3	NR_DBD_ROR	14..108	CDD:143526	71/93 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..127		4/22 (18%)
		NR_LBD_ROR_like	221..461	CDD:132737	85/245 (35%)
		AF-2	456..461		4/4 (100%)