Protein Alignment Hr3 and Vdr

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_033530.2
• Gene: Vdr / 22337
• MGIID: 103076
• Length: 422
• Species: Mus musculus
• Alignment Length: 442
• Identity: 110/442 - (24%)
• Similarity: 197/442 - (44%)
• Gaps: 87/442 - (19%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLG 501
            |.||||:::|.|:..:||||||||||||......:.||.|..|.:.:.||..||.|||::|:.:|
Mouse    24 CGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIG 88

  Fly   502 MSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQ----------LH 556
            |.::.:......:::||.:         ..|.:.:|..||     ..|..|::          .|
Mouse    89 MMKEFILTDEEVQRKREMI---------MKRKEEEALKDS-----LRPKLSEEQQHIIAILLDAH 139

  Fly   557 HNNYNSGGYSN---------NEVGYGSPYGYSASVTPQQTMQY--DISADYVDSTTYEPRSTIID 610
            |..|:. .|::         .:|..||   ||    |:.|:.:  |.|:   :|..|.|...:::
Mouse   140 HKTYDP-TYADFRDFRPPIRADVSTGS---YS----PRPTLSFSGDSSS---NSDLYTPSLDMME 193

  Fly   611 PEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKL 675
            |  .|.:..|:|:       |...:.:..|           |:|.:....:|         |:.:
Mouse   194 P--ASFSTMDLNE-------EGSDDPSVTL-----------DLSPLSMLPHL---------ADLV 229

  Fly   676 TQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYG------DVML 734
            :..||.:|.|||:||||..|:.||||:|||:.:.|:.::|.::...|...:...|      |:..
Mouse   230 SYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITD 294

  Fly   735 PQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLS 799
            ...|.:|     :.|:..:.:....:.:|.|.|.|..|..::.::.|:|.||:....::.:.:..
Mouse   295 VSRAGHT-----LELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRL 354

  Fly   800 MNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPN 851
            .|.::..:...|.| .|...:...::..:.:.|.::..|.:.......|..|
Mouse   355 SNTLQTYIRCRHPP-PGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEN 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	35/86 (41%)
		NR_LBD	620..862	CDD:472173	51/238 (21%)
Vdr	NP_033530.2	NR_DBD_VDR	16..122	CDD:143513	39/111 (35%)
		Hinge. /evidence=ECO:0000250|UniProtKB:P11473	97..126		7/42 (17%)
		NR_LBD_VDR	124..421	CDD:132731	70/328 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..185		10/33 (30%)
		Interaction with coactivator LXXLL motif. /evidence=ECO:0000250|UniProtKB:P13053	241..259		11/17 (65%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473	411..419