Protein Alignment Hr3 and Rarb

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001276689.1
• Gene: Rarb / 218772
• MGIID: 97857
• Length: 482
• Species: Mus musculus
• Alignment Length: 535
• Identity: 132/535 - (24%)
• Similarity: 211/535 - (39%)
• Gaps: 157/535 - (29%)

  Fly   372 PPMPPLTTHKPAATTTATSATSAAAATSAAT-----ASATATSARENSREHSSSSSGSNGAMTAQ 431
            ||:..|..|.|.:..:..|..|...|....|     |::|..:...|:...:.|:|..
Mouse    39 PPLHGLHGHPPPSGCSTPSPASVGQACQRTTGGSQFAASTKWTPSLNAAIETQSTSSE------- 96

  Fly   432 IEII--------------PCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVD 482
             |::              ||.||.|||||.||||..|||||||||||....:.|.|.|:|.||::
Mouse    97 -ELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVIN 160

  Fly   483 RVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQ 547
            :|.||||||||||||.::|||:::|:..| :||::|..:.|.
Mouse   161 KVTRNRCQYCRLQKCFEVGMSKESVRNDR-NKKKKEPSKQEC----------------------- 201

  Fly   548 TPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPE 612
                                                   |..|:::|:.
Mouse   202 ---------------------------------------TESYEMTAEL---------------- 211

  Fly   613 FISHADGDINDVLIKTLAEAHANT----------NTKLEAVHDMFRKQPDVSRILYYKNLGQEEL 667
                      |.|.:.:.:||..|          .|...|.|   |.:.|:.            |
Mouse   212 ----------DDLTEKIRKAHQETFPSLCQLGKYTTNSSADH---RVRLDLG------------L 251

  Fly   668 WLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDV 732
            |...:|..|:.|..|:||||.:|||..|:..|||.|||....::.|:|:.......|:.:.:.|.
Mouse   252 WDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDG 316

  Fly   733 MLPQEAFYTSDSEEMR------LVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTE 791
            :       |.:..:|.      |...:|..|..:..|::.:||..|..::.|:..:|..:...|:
Mouse   317 L-------TLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTK 374

  Fly   792 IQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPA 856
            :.:|....:.|::..:. ...|.|..  :...:|..|.:.|.||....|.:...|::.|..:.|.
Mouse   375 VDKLQEPLLEALKIYIR-KRRPSKPH--MFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPL 436

  Fly   857 LYKELFSIDSQQDLT 871
            :.:.|.:.:..:.||
Mouse   437 IQEMLENSEGHEPLT 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	52/107 (49%)
		NR_LBD	620..862	CDD:472173	59/257 (23%)
Rarb	NP_001276689.1	Modulating	1..114		15/82 (18%)
		NR_DBD_RAR	109..193	CDD:143522	49/84 (58%)
		Hinge	181..209		9/90 (10%)
		NR_LBD_RAR	213..443	CDD:132735	59/254 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..482		2/9 (22%)