Protein Alignment Hr3 and Nr1d1

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_663409.2
• Gene: Nr1d1 / 217166
• MGIID: 2444210
• Length: 615
• Species: Mus musculus
• Alignment Length: 676
• Identity: 173/676 - (25%)
• Similarity: 281/676 - (41%)
• Gaps: 190/676 - (28%)

  Fly   280 AEGEPEDETEPE----------------------PPAPKRLATTRPAQSRPQQQQQQQQQQVKFL 322
            :.|.....|.||                      ||:|....|..||:|              |.
Mouse    19 SSGSSPSRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPARS--------------FG 69

  Fly   323 SDPPALARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTT 387
            |.||:|:..||.||.||.||.|:.|..      |.|..|||:...|
Mouse    70 SAPPSLSDDSSPSSASSSSSSSSSSFY------NGSPPGSLQVAME------------------- 109

  Fly   388 ATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSGVHYGVI 452
                                .|:|.:..:.:|:.:..||.      ::.||||||.:||.||||.
Mouse   110 --------------------DSSRVSPSKGTSNITKLNGM------VLLCKVCGDVASGFHYGVH 148

  Fly   453 TCEGCKGFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQ 516
            .|||||||||||....:.| :|.:|:.|.:.|:||||||.||.:|||.:|||||||:|||:.|::
Mouse   149 ACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKRE 213

  Fly   517 REKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSP-YGYS- 579
            ::::       .|:|::..:.|  ::...:..|..:....|....|.|.|.......:| .|:|
Mouse   214 KQRM-------LAEMQSAMNLA--NNQLSSLCPLETSPTPHPTSGSMGPSPPPAPAPTPLVGFSQ 269

  Fly   580 --------ASVTPQQTMQ---YDISADYVDSTTYEPRSTIIDP-EF-ISHADG------------ 619
                    .|.:|:.||:   ..::..:.:..||........| .| .:||.|
Mouse   270 FPQQLTPPRSPSPEPTMEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPSATTPHRWES 334

  Fly   620 -------DINDVLI--------------------------------------KTLAEAHANTNTK 639
                   :.|::|.                                      ..|...|..:..:
Mouse   335 QGCPSAPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPTHHSCHQPNSNGHRLCPTHVYSAPE 399

  Fly   640 LEAVHDMFRKQPDVSRILY--------YKNLGQ--EELWLDCAEKLTQMIQNIIEFAKLIPGFMR 694
            .||..:..| |.:...:|.        :...|:  :|:|.|.:...|..::.::||||.||||..
Mouse   400 GEAPANSLR-QGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRD 463

  Fly   695 LSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEM---RLVSRIFQT 756
            |||.||:.|||.|:||:.:||.:.|.::....|::    |.:..:...:...|   .|::.:|..
Mouse   464 LSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMF----LSRTTYSLQELGAMGMGDLLNAMFDF 524

  Fly   757 AKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVL 821
            ::.:..|.|||.||.|:.::||:..:|:|:..:..:::|....:.|:|..:..|.   ..:.:..
Mouse   525 SEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNR---PSETSRF 586

  Fly   822 DTLLNNIPNFRDISILHMESLSKFKL 847
            ..||..:|:.|.::.:|.|.|..|::
Mouse   587 TKLLLKLPDLRTLNNMHSEKLLSFRV 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	50/94 (53%)
		NR_LBD	620..862	CDD:472173	64/279 (23%)
Nr1d1	NP_663409.2	Modulating	1..129		36/168 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..120		34/159 (21%)
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:30792350	1..70		12/64 (19%)
		Crucial for activation of GJA1	49..285		96/309 (31%)
		NR_DBD_REV_ERB	128..216	CDD:143540	51/93 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..286		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..337		5/24 (21%)
		NR_LBD	419..612	CDD:472173	55/199 (28%)