DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and Rora

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	NP_038674.1	Gene:	Rora / 19883	MGIID:	104661	Length:	523	Species:	Mus musculus

Alignment Length:	522	Identity:	186/522 - (35%)
Similarity:	279/522 - (53%)	Gaps:	59/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 PAATTTATSATSAAAAT--------SAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCK 438
            |||:...:|.:.|||.:        :...:.|.....|::....|...|.:....|:||||||||
Mouse    10 PAASEPGSSGSEAAAGSRETPLTQDTGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCK 74

  Fly   439 VCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMS 503
            :|||||||:||||||||||||||||||.|...|.|||.|.|::||.:|||||:|||||||.:|||
Mouse    75 ICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMS 139

  Fly   504 RDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPS---SSDQLHHNNYNSGGY 565
            ||||||||||||||:.:..||:.||.|.: |.|........:..||:   |::.|...:.:...|
Mouse   140 RDAVKFGRMSKKQRDSLYAEVQKHRMQQQ-QRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTY 203

  Fly   566 SNNEVGYGSPYGYSAS-------VTPQQTMQYDIS-------ADYVDSTTYEPRSTIIDPEFISH 616
            .:.....||....:.|       .:|.|: ..||:       .||..::.:.|        :.|.
Mouse   204 MDGHTPEGSKADSAVSSFYLDIQPSPDQS-GLDINGIKPEPICDYTPASGFFP--------YCSF 259

  Fly   617 ADGDIN--------DVLIKTLAEAHANT----NTKLEAVHDMFRKQPDVSRILYYKNLGQEELWL 669
            .:|:.:        :.|.:.::::|..|    ..:|:.:......|.::..   |:|..:|.:|.
Mouse   260 TNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIEN---YQNKQREVMWQ 321

  Fly   670 DCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVML 734
            .||.|:|:.||.::||||.|.|||.|.|:|||:|||.||.|:..:||.|..|...|.|.:.....
Mouse   322 LCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYA 386

  Fly   735 PQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLS 799
            ..:.|.:...|:  .:|.:|:..||:..:.|||.|:||:.:.||:..:|:.::...:|::|....
Mouse   387 SPDVFKSLGCED--FISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKI 449

  Fly   800 MNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVV---FPALYKEL 861
            ..|::..|:.||.    :..:|..|:..:...|.:...|.|.|..||..:|::|   ||.|||||
Mouse   450 QLALQHVLQKNHR----EDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKEL 510

  Fly   862 FS 863
            |:
Mouse   511 FT 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
Rora	NP_038674.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		11/52 (21%)
		NR_DBD_ROR	66..160	CDD:143526	71/93 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..183		7/29 (24%)
		NR_LBD_ROR_like	272..511	CDD:132737	77/247 (31%)
		AF-2	506..511		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2649
Isobase	1	0.950	-	0	Normalized mean entropy	S5442
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm42571
orthoMCL	1	0.900	-	-		OOG6_104672
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920