Protein Alignment Hr3 and Ppard

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_035275.1
• Gene: Ppard / 19015
• MGIID: 101884
• Length: 440
• Species: Mus musculus
• Alignment Length: 471
• Identity: 123/471 - (26%)
• Similarity: 213/471 - (45%)
• Gaps: 83/471 - (17%)

  Fly   407 ATSARENSREHSSSS------SGSNGAMTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQ 465
            ::|..:.|:..|.||      .|.:||....:. :.|:|||||:||.||||..||||||||||:.
Mouse    38 SSSCADLSQNSSPSSLLDQLQMGCDGASGGSLN-MECRVCGDKASGFHYGVHACEGCKGFFRRTI 101

  Fly   466 SSVVNYQ-CPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRA 529
            ...:.|: |.|  .|.:.:.|||:|||||.||||.||||.:|::||||.:.::.|:.       |
Mouse   102 RMKLEYEKCDR--ICKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLV-------A 157

  Fly   530 QMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISA 594
            .:.|......:..:.|.:..|.      :.||:  |..|
Mouse   158 GLTASEGCQHNPQLADLKAFSK------HIYNA--YLKN-------------------------- 188

  Fly   595 DYVDSTTYEPRSTIIDPEFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQP--DVSRIL 657
              .:.|..:.|| |:..:...:|...|:|  |:||.:|......| :.|:.:   .|  ::|..:
Mouse   189 --FNMTKKKARS-ILTGKSSHNAPFVIHD--IETLWQAEKGLVWK-QLVNGL---PPYNEISVHV 244

  Fly   658 YYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDL 722
            :|:          |.....:.::.:.||||.||.|..|..:||:.|||.|..|.....::.:::.
Mouse   245 FYR----------CQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK 299

  Fly   723 SQNAVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVR 787
            ....|..|...:..|...:.......::...|:.|.....|:|.:::|||:.:.::|..:|.|:.
Mouse   300 DGLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLM 364

  Fly   788 GNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFK------ 846
            ...:::.:.:..:.|:...|:.||...:   .:...||..:.:.|.:...|.:.:...|
Mouse   365 NVPQVEAIQDTILRALEFHLQVNHPDSQ---YLFPKLLQKMADLRQLVTEHAQMMQWLKKTESET 426

  Fly   847 LQHPNVVFPALYKELF 862
            |.||  :...:||:::
Mouse   427 LLHP--LLQEIYKDMY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	48/94 (51%)
		NR_LBD	620..862	CDD:472173	54/249 (22%)
Ppard	NP_035275.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		4/14 (29%)
		NR_DBD_Ppar	72..155	CDD:143523	47/84 (56%)
		NR_LBD_PPAR	172..439	CDD:132730	65/324 (20%)