Protein Alignment Hr3 and Ppara

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_035274.2
• Gene: Ppara / 19013
• MGIID: 104740
• Length: 468
• Species: Mus musculus
• Alignment Length: 564
• Identity: 131/564 - (23%)
• Similarity: 228/564 - (40%)
• Gaps: 156/564 - (27%)

  Fly   335 SSLSS--FSSISNISSVCKNMASNTS----------------QEGSLKRTKERTPPPMPPLT-TH 380
            |.||.  ...:.||..:.:::...:|                .|||:             :| |.
Mouse    21 SPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSV-------------ITDTL 72

  Fly   381 KPAATTTATSATSAAAATSAATASATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSS 445
            .||::.::.|.....|:|..:..||..                           |.|::||||:|
Mouse    73 SPASSPSSVSCPVIPASTDESPGSALN---------------------------IECRICGDKAS 110

  Fly   446 GVHYGVITCEGCKGFFRRS-QSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKF 509
            |.||||..||||||||||: :..:|..:|.|:  |.:.:.|||:|||||..|||.:|||.:|::|
Mouse   111 GYHYGVHACEGCKGFFRRTIRLKLVYDKCDRS--CKIQKKNRNKCQYCRFHKCLSVGMSHNAIRF 173

  Fly   510 GRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHH---NNYN---------- 561
            |||.:.::.|::.|:      :..:.| ..||...|.:  |...::|.   .|:|
Mouse   174 GRMPRSEKAKLKAEI------LTCEHD-LKDSETADLK--SLGKRIHEAYLKNFNMNKVKARVIL 229

  Fly   562 SGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLI 626
            :|..|||                                          |.|:.|.        :
Mouse   230 AGKTSNN------------------------------------------PPFVIHD--------M 244

  Fly   627 KTLAEAHANTNTKLEA--VHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLT-QMIQNIIEFAKL 688
            :||..|......|:.|  |.|   |:.:|.             :..|.:.:: :.:..:.||||.
Mouse   245 ETLCMAEKTLVAKMVANGVED---KEAEVR-------------FFHCCQCMSVETVTELTEFAKA 293

  Fly   689 IPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDSEEMRLVSRI 753
            ||||..|..:||:.|||.|.:|.....:|.|::.....:.||:..:.:|...........::...
Mouse   294 IPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPK 358

  Fly   754 FQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDV 818
            |..|.....|:|.:::::|:.:.::...:|.|:.....|::|....::.::..|::||   ..|.
Mouse   359 FDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNH---PDDT 420

  Fly   819 TVLDTLLNNIPNFRDISILHMESLSKFKLQHPNVVFPALYKELF 862
            .:...||..:.:.|.:...|.:.:...|....:.....|.:|::
Mouse   421 FLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIY 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	46/94 (49%)
		NR_LBD	620..862	CDD:472173	51/244 (21%)
Ppara	NP_035274.2	NR_DBD_Ppar	101..184	CDD:143523	44/84 (52%)
		NR_LBD_PPAR	201..467	CDD:132730	63/335 (19%)
		Required for heterodimerization with RXRA. /evidence=ECO:0000250	304..433		27/131 (21%)