Protein Alignment Hr3 and Nr1i2

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_035066.1
• Gene: Nr1i2 / 18171
• MGIID: 1337040
• Length: 431
• Species: Mus musculus
• Alignment Length: 466
• Identity: 119/466 - (25%)
• Similarity: 194/466 - (41%)
• Gaps: 115/466 - (24%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCP-RNKQCVVDRVNRNRCQYCRLQKCLKL 500
            |:|||||::|.|:.|:|||||||||||:....|..:|| |...|.:.|..|.:||.|||:|||:.
Mouse    38 CRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLES 102

  Fly   501 GMSRD------AVKFGR--MSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHH 557
            ||.::      ||:..|  :.:|:|||:|                ||
Mouse   103 GMKKEMIMSDAAVEQRRALIKRKKREKIE----------------AP------------------ 133

  Fly   558 NNYNSGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDS--TTYEPRSTIIDPEFISHADGD 620
                             |.|.......||.:..::....:.:  ||:........|. :.|:..:
Mouse   134 -----------------PPGGQGLTEEQQALIQELMDAQMQTFDTTFSHFKDFRLPA-VFHSGCE 180

  Fly   621 INDVLIKTLAEAHANTNTKLEAVHD----------------MFRKQPDVSRILYYKNLGQEELWL 669
            :.:.|..:|.|..|   |..:.:.|                ::..||.      .|:.|:|.:.|
Mouse   181 LPEFLQASLLEDPA---TWSQIMKDRVPMKISLQLRGEDGSIWNYQPP------SKSDGKEIIPL 236

  Fly   670 --DCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQN------- 725
              ..|:..|.|.:.:|.|||:|..|..|..:|||.|||..:||:.|:|.:.:.|....
Mouse   237 LPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECGRL 301

  Fly   726 AVLYGDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNT 790
            |..:.|   |...|      :..|:..:.:....:.:|:|.:.|..|.|::.|..|:|.||...:
Mouse   302 AYCFED---PNGGF------QKLLLDPLMKFHCMLKKLQLHKEEYVLMQAISLFSPDRPGVVQRS 357

  Fly   791 ---EIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKLQHPNV 852
               ::|..|.|::.|.   :|.:. |......:...::..:...|.|:....:.|.:.:..||..
Mouse   358 VVDQLQERFALTLKAY---IECSR-PYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFA 418

  Fly   853 VFPALYKELFS 863
            .  .|.:||||
Mouse   419 T--PLMQELFS 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	45/95 (47%)
		NR_LBD	620..862	CDD:472173	61/269 (23%)
Nr1i2	NP_035066.1	NR_DBD_like	37..124	CDD:413390	40/85 (47%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	63..89		8/25 (32%)
		Hinge	105..142		12/87 (14%)
		NR_LBD	140..425	CDD:472173	66/309 (21%)