Protein Alignment Hr3 and nhr-23

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001020975.1
• Gene: nhr-23 / 172460
• WormBaseID: WBGene00003622
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 493
• Identity: 184/493 - (37%)
• Similarity: 249/493 - (50%)
• Gaps: 115/493 - (23%)

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            ::||||:|||||||||||||||||||||||||||||||||:|||||||.|.||||||||||||||
 Worm   154 VSAQIEVIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSIVNYQCPRQKNCVVDRVNRNRCQYC 218

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSS----- 552
            ||:||::||||||||||||||||||||||||||.|:   ...::.....::|...:|..|
 Worm   219 RLKKCIELGMSRDAVKFGRMSKKQREKVEDEVRMHK---ELAANGLGYQAIYGDYSPPPSHPSYC 280

  Fly   553 -DQLHHNNYNSGGYSNNEVGYGSPYGYSASV-----TPQQTMQYDISADYVDSTTYEPRSTIIDP 611
             ||..:.:|.||  ::..|.     |||.:|     ||.....|..:....:.|.|
 Worm   281 FDQSMYGHYPSG--TSTPVN-----GYSIAVAATPTTPMPQNMYGATPSSTNGTQY--------- 329

  Fly   612 EFISH-ADG-----------DINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQ 664
              ::| |.|           |:...:|:...:.|::..|:    |.:....||.  |.:....|.
 Worm   330 --VAHQATGGSFPSPQVPEEDVATRVIRAFNQQHSSYTTQ----HGVCNVDPDC--IPHLSRAGG 386

  Fly   665 EELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLY 729
            .||:   |.:|..:||.||||||.|.|||.|.|:.||.|||...|||::|..:...::...||..
 Worm   387 WELF---ARELNPLIQAIIEFAKSIDGFMNLPQETQIQLLKGSVFELSLVFAAMYYNVDAQAVCG 448

  Fly   730 GDVMLPQEAFYTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQR 794
            ....:|.......|..||:|:..:..|.:.|..|:..::||||
 Worm   449 ERYSVPFACLIAEDDAEMQLIVEVNNTLQEIVHLQPHQSELAL---------------------- 491

  Fly   795 LFNLSMNAIRQELETNHAPLKGDVTVLDT-----------------------LLNNIPNFRDISI 836
               |:...|.:::.::|.     :.:|||                       :.:.|...:|:..
 Worm   492 ---LAAGLILEQVSSSHG-----IGILDTATIATAETLKNALYQSVMPRIGCMEDTIHRIQDVET 548

  Fly   837 -------LHMESLSKFKLQHP--NVVFPALYKELFSID 865
                   ||.|:|..|::..|  :...||||||||:.|
 Worm   549 RIRQTARLHQEALQNFRMSDPTSSEKLPALYKELFTAD 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	86/93 (92%)
		NR_LBD	620..862	CDD:472173	70/273 (26%)
nhr-23	NP_001020975.1	NR_DBD_ROR	156..250	CDD:143526	86/93 (92%)
		NR_LBD	384..580	CDD:472173	59/228 (26%)