Protein Alignment Hr3 and vdr

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: XP_002935703.1
• Gene: vdr / 100491661
• XenbaseID: XB-GENE-486505
• Length: 420
• Species: Xenopus tropicalis
• Alignment Length: 470
• Identity: 110/470 - (23%)
• Similarity: 183/470 - (38%)
• Gaps: 122/470 - (25%)

  Fly   437 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYCRLQKCLKLG 501
            |.|||||::|.|:..:||||||||||||......:.||.|..|.:.:.||..||.|||::|:.:|
 Frog    24 CGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKAVFTCPFNGDCRITKDNRRHCQSCRLKRCVDIG 88

  Fly   502 MSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHHNNYNSGGYS 566
            |.::.:......:::||.:         ..|.:.:|..:|     ..|..|::
 Frog    89 MMKEFILTDEEVQRKREMI---------TKRKEEEALKES-----MRPKMSEE------------ 127

  Fly   567 NNEVGYGSPYGYSASVTPQQTMQYDISAD---------YVDSTTYEP-----------RSTIIDP 611
                              ||.| .|:..|         |.|...:.|           ||:.|..
 Frog   128 ------------------QQKM-IDVLVDAHRKTFDTTYSDFGQFRPPVRENVCKRITRSSSILT 173

  Fly   612 EFISHADGDINDVLIKTLAEAHANTNTKLEAVHDMFRKQPDVSRILYYK---------------N 661
            :..|..|.|:                         |...||.|...::.               .
 Frog   174 QGSSSEDSDV-------------------------FTSSPDCSEHGFFSAGSLFGHFEHSSMDGK 213

  Fly   662 LGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNA 726
            .|...:....|:.::..||.:|.|||:||||..|..:|||.|||:...|:.::|.::...|...:
 Frog   214 AGDLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLIAEDQIALLKSSVIEVIMLRSNQSFSLDDMS 278

  Fly   727 VLYGDVMLPQEAF------YTSDSEEMRLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNG 785
            ...|     .|.|      .|.....|.|:..:.:....:.:|.|.|.|..|..::.:|.|:|.|
 Frog   279 WTCG-----SEDFKYKVDDVTQAGHNMELLEPLVKFQVGLKKLNLHEEEHVLLMAICILSPDRPG 338

  Fly   786 VRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPNFRDISILHME---SLSKFKL 847
            |:....::.:.:.....::..:...|.| .|...:...::..:.:.|.::..|.:   |:| |..
 Frog   339 VQDKALVESIQDRLSATLQTYILCKHPP-PGSRLLYAKMIQKLADLRSLNEEHSKQYRSIS-FLP 401

  Fly   848 QHPNVVFPALYKELF 862
            :|...:.| |..|:|
 Frog   402 EHSMQLTP-LVLEVF 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	36/86 (42%)
		NR_LBD	620..862	CDD:472173	55/265 (21%)
vdr	XP_002935703.1	NR_DBD_VDR	16..122	CDD:143513	39/111 (35%)
		NR_LBD_VDR	124..419	CDD:132731	70/356 (20%)