Protein Alignment Hr3 and nr1d1

DIOPT Version :10

• Sequence 1: NP_001334718.1
• Gene: Hr3 / 36073
• FlyBaseID: FBgn0000448
• Length: 871
• Species: Drosophila melanogaster
• Sequence 2: NP_001093675.1
• Gene: nr1d1 / 100101679
• XenbaseID: XB-GENE-478094
• Length: 522
• Species: Xenopus tropicalis
• Alignment Length: 561
• Identity: 151/561 - (26%)
• Similarity: 261/561 - (46%)
• Gaps: 99/561 - (17%)

  Fly   323 SDPPALARSSSFSSLSSFSSISNISSVCKNMASNTSQEGSLKRTKERTPPPMPPLTTHKPAATTT 387
            |.|...:..|.:|..||.|..|.:|.....                     :||..:|..:|:::
 Frog    22 SSPNRTSPVSMYSDCSSGSPQSGVSHYANY---------------------LPPSPSHSYSASSS 65

  Fly   388 ATSATSAAAATSAATAS------ATATSARENSREHSSSSSGSNGAMTAQIEIIPCKVCGDKSSG 446
            .:...::..::....||      |....:|.:..:.|||.:..||.      ::.||||||.:||
 Frog    66 GSGGEASPRSSYGLAASPGGLHVALDDGSRVSPSKTSSSITKLNGM------VLLCKVCGDVASG 124

  Fly   447 VHYGVITCEGCKGFFRRSQSSVVNY-QCPRNKQCVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFG 510
            .||||..|||||||||||....:.| :|.:|:.|.:.|:||||||.||.:|||.:|||||||:||
 Frog   125 FHYGVHACEGCKGFFRRSIQQNIQYKKCLKNETCSIVRINRNRCQQCRFRKCLSVGMSRDAVRFG 189

  Fly   511 RMSKKQREKVEDEVRFHRAQ---------MRAQSDAAPDSSVYDTQTPSSSDQL-----HHNNYN 561
            |:.|::::::..|:  |.|.         .|:.....|.........||||..:     |.....
 Frog   190 RIPKREKQRMLAEM--HSAMNHIASGHFGRRSPIPLQPHQQQQQQLHPSSSPLMGTAPCHSPTSL 252

  Fly   562 SGGYSNNEVGYGSPYGYSASVTPQQTMQYDISADYVDSTTYEPRSTIIDPEFISHADGDINDVLI 626
            ...||.          |...:||.::...:...|.:...:...|...:      :|:..:|.
 Frog   253 PDAYSQ----------YPQQLTPPRSPSPEHMDDVISQVSMAHRQIFV------YANDKVNK--- 298

  Fly   627 KT------------LAEAHANTNTKLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMI 679
            ||            ..::|.|.|.:|....:...:...|..:        :|:|.|.:...|..:
 Frog   299 KTSWDHPQPCWSHDTEDSHGNHNIRLACPMNALHRGGPVRSV--------QEVWEDFSLSFTPAV 355

  Fly   680 QNIIEFAKLIPGFMRLSQDDQILLLKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYTSDS 744
            :.::|||:.||||..|:|:||:.|||.|:||:.:||.:.|.|..::::.:    |....:...:.
 Frog   356 REVVEFARHIPGFKDLTQNDQVTLLKAGTFEVLMVRFASLFDAREHSLRF----LSGATYSLPEL 416

  Fly   745 EEM---RLVSRIFQTAKSIAELKLTETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQE 806
            ..|   .|:|.:|..::.::.|.|::.||.::.:|||:..:|:|:..::.:::|....:.|:| .
 Frog   417 HAMGMGELLSSMFDFSEKLSSLSLSQEELGIFTALVLVSADRSGMENSSLVEQLQETLIRALR-S 480

  Fly   807 LETNHAPLKGDVTVLDTLLNNIPNFRDISILHMESLSKFKL 847
            |...::|  .|.:....||..:|:.|.::.:|.|.|..|::
 Frog   481 LILKNSP--NDTSRFTKLLLRLPDLRTLNNMHSEKLLSFRV 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	NR_DBD_ROR	430..524	CDD:143526	50/94 (53%)
		NR_LBD	620..862	CDD:472173	61/243 (25%)
nr1d1	NP_001093675.1	NR_DBD_REV_ERB	110..198	CDD:143540	51/93 (55%)
		NR_LBD	331..519	CDD:472173	54/202 (27%)