DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr3 and rorc

DIOPT Version :9

Sequence 1:	NP_001334718.1	Gene:	Hr3 / 36073	FlyBaseID:	FBgn0000448	Length:	871	Species:	Drosophila melanogaster
Sequence 2:	XP_001344049.3	Gene:	rorc / 100004847	ZFINID:	ZDB-GENE-110411-42	Length:	480	Species:	Danio rerio

Alignment Length:	494	Identity:	176/494 - (35%)
Similarity:	256/494 - (51%)	Gaps:	78/494 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 MTAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRNKQCVVDRVNRNRCQYC 492
            |.||||:||||:||||||||||||||||||||||||||||.|.|.|.|...|.:||.:|||||.|
Zfish     2 MRAQIEVIPCKICGDKSSGVHYGVITCEGCKGFFRRSQSSSVQYSCSRQSNCPIDRASRNRCQSC 66

  Fly   493 RLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRFHRAQMRAQSDAAPDSSVYDTQTPSSSDQLHH 557
            ||:||:..||||||||||||||:||:.:..||..||...|.|:     :||.:.|...:
Zfish    67 RLKKCVAQGMSRDAVKFGRMSKRQRDSLFAEVERHRQHQRLQA-----NSVQEPQPLQA------ 120

  Fly   558 NNYNSGGYSNNEVGY---GSPYGYSASVTPQ---------------------QTMQY-------- 590
              |.|...:..:..:   ..|..|..||.|:                     |.:.|
Zfish   121 --YRSSKDTREQPSHLIPPLPAAYPFSVEPELAGCPAEVIPYLDCHIVEAQTQGLAYRVPLRRGE 183

  Fly   591 --DISADY-VDSTTYEPRSTI-----------IDPE--FISHADGDINDVLIKTLAEAHANTNT- 638
              .:||.. .:||...|.|.:           .|||  |.|:......:.|..::..:|..|..
Zfish   184 NNSLSAGRGFESTRSTPESILNMTGSEMGFHPFDPESSFFSYPTSLQTEELAASIIRSHKETTQY 248

  Fly   639 KLEAVHDMFRKQPDVSRILYYKNLGQEELWLDCAEKLTQMIQNIIEFAKLIPGFMRLSQDDQILL 703
            :||.:..:..|......:..|::...:|:|..||.:|:..:|.::||||.||||.:|.|:|||.|
Zfish   249 RLEELQALRWKVFSREEVHIYQSKPVDEMWQYCAVRLSDAVQYVVEFAKRIPGFRQLCQNDQIAL 313

  Fly   704 LKTGSFELAIVRMSRLLDLSQNAVLYGDVMLPQEAFYT---SDSEEMRLVSRIFQTAKSIAELKL 765
            ||:||.|:.:|||:|:.:.:.|.|.:.......|.|.:   ||     |::.:|:.|.::..|:|
Zfish   314 LKSGSMEVVLVRMTRMFNTANNTVFFDGKYAGTELFKSLACSD-----LIAAVFEFANNLCALRL 373

  Fly   766 TETELALYQSLVLLWPERNGVRGNTEIQRLFNLSMNAIRQELETNHAPLKGDVTVLDTLLNNIPN 830
            .|.::|::.:::|:.|:|..:.....:||:......|:|..|..::     ..::|..|...:|.
Zfish   374 NEQQMAVFTAMILINPDRPCLEDRERVQRVRTEVELALRHILHRDN-----QESLLQKLYQRVPV 433

  Fly   831 FRDISILHMESLSKFKLQHPNVV---FPALYKELFSIDS 866
            .|.:..||:|.|..|:..:|..|   ||.||||||..|:
Zfish   434 LRSMCALHIEKLQWFRQLYPLTVHSLFPPLYKELFGSDA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr3	NP_001334718.1	None
rorc	XP_001344049.3	NR_DBD_ROR	4..98	CDD:143526	69/93 (74%)
rorc	XP_001344049.3	NR_LBD_ROR_like	232..468	CDD:132737	74/245 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2662
OMA	1	1.010	-	-		QHG47287
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001077
OrthoInspector	1	1.000	-	-		otm24275
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45805
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X649
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.070