DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mlt and Tbce

DIOPT Version :9

Sequence 1:	NP_001260853.1	Gene:	mlt / 36072	FlyBaseID:	FBgn0265512	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_610197.2	Gene:	Tbce / 35532	FlyBaseID:	FBgn0033055	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	93/428 - (21%)
Similarity:	162/428 - (37%)	Gaps:	128/428 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LDLAQNKLSDWSEVFSILEHMPRIEFLNLSKNQLASPIGTLPT--APT------INLKSLVLNGT 146
            |:::...:.:|..|.||.:.:|.:..||||.|:|..|..:..|  .|:      |||:|.    .
  Fly   161 LNVSHTLIWNWEIVASIAQQLPSLTNLNLSSNRLVLPTSSQITELEPSFRQLKRINLRSC----G 221

  Fly   147 YLDWACVDTLLKNLPVLQELHLSLNNYRQVL-IDAEEAEQRLQETETPEETERRITKAHPALKTL 210
            :.||..|.......|.:..|.|..|:..|:. :|..:..::|.|.:                  |
  Fly   222 FSDWKDVMHTALLWPNILSLGLQENSLGQLAEVDRTKIFKQLHELD------------------L 268

  Fly   211 HFTGNPVEHWQEICRLGRLFP---------NLEALVLADCPIKSLQAEESSETHRYFPSLRLLNL 266
            |.|.  :..:.::.:||.|..         .:|.:.|.||        :|.|....|.||..|||
  Fly   269 HRTN--IMDFDQVTKLGNLTTLRLLNIMENGIEEIKLPDC--------DSQEKLNIFVSLEQLNL 323

  Fly   267 SSAQLDSWA-AIDELAKFSELRNL-RVKHWPLWESLECTEHERRQLLIARLPNVEMLNGGGKISS 329
            ....:.:.| |.:||.|..:|:.| :..|      |:....|.....:|.:.:::.:| ..::::
  Fly   324 LHNPIWNEADAFNELDKLPQLKRLSKTPH------LKSNFDEMFSKAVASIASLQFIN-KAEVTA 381

  Fly   330 DER----------------------VDSERAFVRYYMDKP----EEERPARYQELLQIHGKLDPL 368
            ::|                      .||.|.|.|.:...|    :...||.:....|  .|...|
  Fly   382 EQRRGAEYDIWKKYALDWMQATQGGTDSLREFCRRHRTYPLLVKKYGSPADFVPRSQ--AKQSNL 444

  Fly   369 VNVSLKP-------DKRVKVLFTYNDVSESRFVDIYLTVNDLKVKLEKLVGLAPNKMRLYYLDQD 426
            :|||::.       :|:|..:.|..            |:..|.:|..:|.|..|   :|.|:|
  Fly   445 INVSIRHQLTGETWEKKVPRMITVQ------------TLQGLVMKRFRLSGDVP---QLCYVD-- 492

  Fly   427 YKEFGPEEMRYPN---------KQLYSYNIQSGDEIII 455
                    ..:|:         |.|..|::|..|.:::
  Fly   493 --------ALHPDLVVPLDNNAKTLDFYSVQEHDTVLV 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mlt	NP_001260853.1	LRR	<46..>177	CDD:227223	27/94 (29%)
		LRR_RI	57..>276	CDD:238064	49/204 (24%)
		leucine-rich repeat	87..112	CDD:275380	5/21 (24%)
		leucine-rich repeat	113..137	CDD:275380	9/31 (29%)
		leucine-rich repeat	138..162	CDD:275380	5/23 (22%)
		leucine-rich repeat	207..232	CDD:275380	6/33 (18%)
		leucine-rich repeat	233..260	CDD:275380	7/26 (27%)
		leucine-rich repeat	261..285	CDD:275380	9/24 (38%)
		UBQ	379..456	CDD:294102	17/86 (20%)
Tbce	NP_610197.2	CAP_GLY	14..79	CDD:214997
		LRR_RI	<148..268	CDD:330982	30/128 (23%)
		leucine-rich repeat	158..183	CDD:275380	5/21 (24%)
		leucine-rich repeat	184..211	CDD:275380	9/26 (35%)
		leucine-rich repeat	212..238	CDD:275380	8/29 (28%)
		leucine-rich repeat	239..262	CDD:275380	5/22 (23%)
		leucine-rich repeat	263..287	CDD:275380	8/43 (19%)
		leucine-rich repeat	288..317	CDD:275380	7/36 (19%)
		leucine-rich repeat	318..343	CDD:275380	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470237
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR15140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2217
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970