DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mlt and Tbcel

DIOPT Version :9

Sequence 1:	NP_001260853.1	Gene:	mlt / 36072	FlyBaseID:	FBgn0265512	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_038937343.1	Gene:	Tbcel / 315591	RGDID:	1308880	Length:	485	Species:	Rattus norvegicus

Alignment Length:	454	Identity:	165/454 - (36%)
Similarity:	242/454 - (53%)	Gaps:	73/454 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PRLSPL---TSVPALLVLNDCDIDSAGDFDSIREKCQRVRELDLAQNKLSDWSEVFSILEHMPRI 113
            |:.||:   .::|::||||.|.|..|||...|...|..|.||||:.|||.||.||..|:.::|::
  Rat    56 PQGSPMKDRLNLPSVLVLNSCGITCAGDEREIAAFCAHVSELDLSDNKLQDWHEVSKIVSNVPQL 120

  Fly   114 EFLNLSKNQLASPIGTLPTAPTIN-LKSLVLNGTYLDWACVDTLLKNLPVLQELHLSLNNYRQVL 177
            ||||||.|.|:..:.....|.:.: ::.||||.:...|..|.|:|:.||.|:||.|.||:|..|.
  Rat   121 EFLNLSSNPLSLSVLERTCAGSFSGVRKLVLNNSKASWETVHTILQELPDLEELFLCLNDYETVS 185

  Fly   178 IDAEEAEQRLQETETPEETERRITKAHPALKTLHFTGNPVEHWQEICRLGRLFPNLEALVLADCP 242
            ..:                    ...| :||.||.|.|.::.|.||.:||.:||:|:.||||:..
  Rat   186 CPS--------------------VCCH-SLKLLHITDNNLQEWTEIRKLGVMFPSLDTLVLANNH 229

  Fly   243 IKSLQAEESSETHRYFPSLRLLNLSSAQLDSWAAIDELAKFSELRNLRVKHWPLWESLECTEHER 307
            :.::: |.:....|.||:||.::|..:.|.||..||:|..|.:|..:|:...||.:..  |..||
  Rat   230 VNAIE-EPADSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPY--TTEER 291

  Fly   308 RQLLIARLPNVEMLNGGGKISSDERVDSERAFVRYYMDKPEEERPAR------------------ 354
            |:|::||||:|..|| |..::..||.||||.|:|||:|.|:||.|.|
  Rat   292 RKLVVARLPSVSKLN-GSVVTDGEREDSERFFIRYYVDVPQEEVPFRIRAPRIIPLLQGQPGLQG 355

  Fly   355 -------------------------YQELLQIHGKLDPLVNVSLKPDKRVKVLFTYNDVSESRFV 394
                                     |.||:..:|||:||..|.|:|....||...:||..|...:
  Rat   356 VFQDSQAYIKRTLSQKEKRGRILWWYHELITKYGKLEPLAEVDLRPQSSAKVEVHFNDQVEEVSI 420

  Fly   395 DIYLTVNDLKVKLEKLVGLAPNKMRLYYLDQDYKEFGPEEMRYPNKQLYSYNIQSGDEIIIDAK 458
            .:..||.:||.:|:.||.|..:.|.|||.|.: ..||||||:|.::.|:|:.|:.||:|.:::|
  Rat   421 RLDQTVAELKRQLKTLVQLPTSSMLLYYFDHE-APFGPEEMKYSSRALHSFGIRDGDKIFVESK 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mlt	NP_001260853.1	LRR	<46..>177	CDD:227223	55/128 (43%)
		LRR_RI	57..>276	CDD:238064	82/222 (37%)
		leucine-rich repeat	87..112	CDD:275380	13/24 (54%)
		leucine-rich repeat	113..137	CDD:275380	9/23 (39%)
		leucine-rich repeat	138..162	CDD:275380	9/23 (39%)
		leucine-rich repeat	207..232	CDD:275380	12/24 (50%)
		leucine-rich repeat	233..260	CDD:275380	8/26 (31%)
		leucine-rich repeat	261..285	CDD:275380	10/23 (43%)
		UBQ	379..456	CDD:294102	31/76 (41%)
Tbcel	XP_038937343.1	LRR	<65..>243	CDD:227223	73/199 (37%)
		leucine-rich repeat	70..90	CDD:275380	10/19 (53%)
		leucine-rich repeat	96..119	CDD:275380	12/22 (55%)
		leucine-rich repeat	120..148	CDD:275380	9/27 (33%)
		leucine-rich repeat	171..193	CDD:275380	9/42 (21%)
		leucine-rich repeat	194..219	CDD:275380	12/24 (50%)
		LRR_9	<209..322	CDD:405295	48/116 (41%)
		leucine-rich repeat	220..246	CDD:275380	8/26 (31%)
		leucine-rich repeat	247..271	CDD:275380	10/23 (43%)
		Ubl_TBCEL	398..483	CDD:340565	33/85 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353678
Domainoid	1	1.000	53	1.000	Domainoid score	I11126
eggNOG	1	0.900	-	-		E1_KOG2982
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16120
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2858
OMA	1	1.010	-	-		QHG49290
OrthoDB	1	1.010	-	-		D1495296at2759
OrthoFinder	1	1.000	-	-		FOG0006363
OrthoInspector	1	1.000	-	-		oto97122
orthoMCL	1	0.900	-	-		OOG6_107210
Panther	1	1.100	-	-	LDO	PTHR15140
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810