DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mlt and coel-1

DIOPT Version :9

Sequence 1:	NP_001260853.1	Gene:	mlt / 36072	FlyBaseID:	FBgn0265512	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_741764.1	Gene:	coel-1 / 180700	WormBaseID:	WBGene00016866	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	474	Identity:	138/474 - (29%)
Similarity:	237/474 - (50%)	Gaps:	84/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLLEALERKYFAECEFENAHQPELHKRSDLPNDFTVTKCGGRMEFSIFIPRLSP--LTSVPA--L 63
            :|:.:||:||..:.|             |:..|...|...|          .||  :.|..|  |
Worm     7 TLVRSLEQKYLDDDE-------------DIVQDIIFTGFTG----------CSPCKMASQRALEL 48

  Fly    64 LVLNDCDIDSAGDFDSIREKCQRVRELDLAQNKLSDWSEVFSILEHMPRIEFLNLSKNQL----- 123
            ||||:.:||:.||.:.:......|.|.||..|::|.||::..||:::|.:..||:..|.|
Worm    49 LVLNNMNIDTIGDSEKLATLASHVSEADLGWNQISKWSDIACILKNLPHLRVLNIGHNPLNPVID 113

  Fly   124 -ASPIGTLPTAPTINLKSLVLNGTYLDWACVDTLLKNLPVLQELHLSLNNYRQVLIDAEEAEQRL 187
             ..|:.||.|        ::||||:|.:..:.:.|..||.:.|||:|.|.:.    |.::.::.:
Worm   114 HELPVSTLHT--------IILNGTHLPFKTLQSFLSVLPKVTELHMSDNQFN----DDDDCDEPI 166

  Fly   188 QETETPEETERRITKAHPALKTLHFTGNPVEHWQEICRLGRLFPNLEALVLADCPIKSLQAEESS 252
            ..|                ::|:|........|..:..:.:.|||:.::.:.:.|:|.:
Worm   167 STT----------------VRTVHLNRCGFLKWSSVMNVVKRFPNVCSVFVCENPLKDV------ 209

  Fly   253 ETH-RYF---PSLRLLNLSSAQLDSWAAIDELAKFSELRNLRVKHWPLWESLECTEHERRQLLIA 313
             || ::|   |....|||:...:|||.::|:|.:.:.:.:|||.:.||.::|  |..||..|:|.
Worm   210 -THCKHFEQLPFWNFLNLAKTSIDSWDSLDQLNRMTSISDLRVPNIPLLDAL--TNEERLHLIIG 271

  Fly   314 RLPNVEMLNGGGKISSDERVDSERAFVRYYMDKPEEERPARYQELLQIHGKLDPLVNVSLKPDKR 378
            ||.::.:|| |.||||::|..|||.|:|||.:  ::|:|.:|:.|:..||.|:.||.:.|.|.|.
Worm   272 RLHHLRVLN-GSKISSEQREQSERFFIRYYQE--QKEKPLQYKTLIDKHGNLEKLVTIDLTPKKE 333

  Fly   379 --VKVLFTYNDVSESRFVDIYLTVNDLKVKLEKLVGLAPNKMRLYYLDQDYK--EFGPEEMRYPN 439
              ||:|....:|::...:.:..||.|....|:..||:...:|:|:.|.:|.:  :|...:...|
Worm   334 AVVKILCEEKEVNQEITISLEPTVLDFMKILDPKVGVKFTRMKLFLLREDGRTDDFSSSDYNMP- 397

  Fly   440 KQLYSYNIQSGDEIIIDAK 458
              |:.:.|:.||..::..|
Worm   398 --LHYFKIEDGDSFLVQEK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mlt	NP_001260853.1	LRR	<46..>177	CDD:227223	45/140 (32%)
		LRR_RI	57..>276	CDD:238064	63/230 (27%)
		leucine-rich repeat	87..112	CDD:275380	10/24 (42%)
		leucine-rich repeat	113..137	CDD:275380	8/29 (28%)
		leucine-rich repeat	138..162	CDD:275380	7/23 (30%)
		leucine-rich repeat	207..232	CDD:275380	4/24 (17%)
		leucine-rich repeat	233..260	CDD:275380	5/30 (17%)
		leucine-rich repeat	261..285	CDD:275380	8/23 (35%)
		UBQ	379..456	CDD:294102	20/78 (26%)
coel-1	NP_741764.1	leucine-rich repeat	46..64	CDD:275378	9/17 (53%)
		leucine-rich repeat	65..97	CDD:275378	10/31 (32%)
		leucine-rich repeat	98..117	CDD:275378	4/18 (22%)
		leucine-rich repeat	121..145	CDD:275378	9/31 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167171
Domainoid	1	1.000	167	1.000	Domainoid score	I2331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16120
Inparanoid	1	1.050	191	1.000	Inparanoid score	I2560
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49290
OrthoDB	1	1.010	-	-		D1495296at2759
OrthoFinder	1	1.000	-	-		FOG0006363
OrthoInspector	1	1.000	-	-		oto19203
orthoMCL	1	0.900	-	-		OOG6_107210
Panther	1	1.100	-	-	LDO	PTHR15140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2217
SonicParanoid	1	1.000	-	-		X4632
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940