DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNQ and Kcnb2

DIOPT Version :10

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_001091998.1 Gene:Kcnb2 / 98741 MGIID:99632 Length:907 Species:Mus musculus


Alignment Length:989 Identity:198/989 - (20%)
Similarity:321/989 - (32%) Gaps:375/989 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFRMEIL 113
            :.:|::.||:|....|  |...|.:..:|.:.:|||: :|:.|.:|:..:       .|..:|.:
Mouse   176 RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL-NTLPELQENDEFGQPSDNRKLAHVEAV 239

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||||:..|..||.         .:.||.|.|..:||::.||...|.:.:..|.        
Mouse   240 CIAWFTMEYLLRFLSSP---------NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQN 295

  Fly   171 -----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFL 230
                 |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.|
Mouse   296 VRRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL 352

  Fly   231 VYMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            |:..|||.: .||::...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.
Mouse   353 VFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 417

  Fly   295 SGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSF 359
            :.|:...::|:||:..|:||:                                       |....
Mouse   418 NNFSEFYKEQKRQEKAIKRRE---------------------------------------ALERA 443

  Fly   360 KHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNG 424
            |.|.|.|                              |......:.|::..|:.:||     :.|
Mouse   444 KRNGSIV------------------------------SMNLKDAFARSMELIDVAVE-----KAG 473

  Fly   425 KSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQ--FPDRNRDRDQDRRGHGE 487
            :|.|   ::|||.:.                    .||.|....|:  ..:.:.::..:.:....
Mouse   474 ESAN---TKDSVDDN--------------------HLSPSRWKWARKALSETSSNKSYENKYQEV 515

  Fly   488 GEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRDE---DEV 549
            .:.|..|.                         |.:|.|        ::.:.|.|.:.|   :|:
Mouse   516 SQNDSHEH-------------------------LNNTSS--------SSPQHLSAQKLEMLYNEI 547

  Fly   550 HKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPRCTQL 614
            .|       |.|                               .|.|||  |...:.:.| |.  
Mouse   548 TK-------TQP-------------------------------HSHPNP--DCQEQPERP-CV-- 569

  Fly   615 TNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGKQG 679
                                  ::|.::..:|....||.|....:::  |.|             
Mouse   570 ----------------------YEEEIEMEEVICPQEQLAVAQTEVI--VDM------------- 597

  Fly   680 SKAKDVYASKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKP 744
             |:.....|..|.|:...:.||.                         |||..      |.||..
Mouse   598 -KSTSSIDSFTSCATDFTETERS-------------------------PLPPP------SASHLQ 630

  Fly   745 LHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTP---TTTTDAIATQT 806
            :....:|...|..:|..|          .|.|..|.......|.......|   |...||.|:..
Mouse   631 MKFPTDLPGTDEHQRARA----------PPFLTLSRDKGPAAREAAVDYAPIDITVNLDAGASHG 685

  Fly   807 PMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRI 871
            |:.|  ...:.:.|||:..|..|.|...:.|  |.   |||.....|   ..||:.|        
Mouse   686 PLQP--DSASDSPKSSLKGSNPLKSRSLKVN--FQ---ENRASAPQT---PPSTARP-------- 732

  Fly   872 TIPDEGADSLDSSAKPTPPDSSIILIDEYED------FEEED-LNCEGE----MDHFPTWEI--- 922
             :|...||    ....||...|.||::|...      .|.:| .:|:|.    ...||..::   
Mouse   733 -LPVTTAD----FPLTTPQHMSTILLEEALPQGQPPLLEADDSAHCQGPSKGFSPRFPKQKLFPF 792

  Fly   923 ---------DSDIGVEVD-VD-----------------ADADGDCDESTEDTALLQCATRTAIVI 960
                     :.|.|.:.| :|                 ||..||..:|..:...:..:       
Mouse   793 SSRERRSFTEIDTGEDEDFLDLQRSRPDKQADPSPNCLADKPGDARDSLREEGCVGSS------- 850

  Fly   961 TPISPVSSAHNLQQ 974
               ||.::.||.:|
Mouse   851 ---SPQNTDHNCRQ 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 71/255 (28%)
KCNQ_channel <619..719 CDD:460954 13/99 (13%)
Kcnb2NP_001091998.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
BTB_POZ_KCNB2 19..145 CDD:349719
Ion_trans 192..428 CDD:459842 70/253 (28%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 381..386 4/4 (100%)
Kv2channel 471..755 CDD:397541 86/484 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..534 5/63 (8%)
FFAT. /evidence=ECO:0000250|UniProtKB:Q92953 605..611 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 680..742 22/84 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..859 18/107 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 887..907
Blue background indicates that the domain is not in the aligned region.

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