Protein Alignment KCNQ and KCNB2

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_004761.2
• Gene: KCNB2 / 9312
• HGNCID: 6232
• Length: 911
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 156/703 - (22%)
• Similarity: 256/703 - (36%)
• Gaps: 217/703 - (30%)

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFRMEIL 113
            :.:|::.||:|....|  |...|.:..:|.:.:|||: :|:.|.:|...:       .|..:|.:
Human   176 RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL-NTLPELQETDEFGQLNDNRQLAHVEAV 239

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||||:..|..||.         .:.||.|.|..:||::.||...|.:.:..|.
Human   240 CIAWFTMEYLLRFLSSP---------NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQN 295

  Fly   171 -----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFL 230
                 |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.|
Human   296 VRRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL 352

  Fly   231 VYMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            |:..|||.: .||::...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.
Human   353 VFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 417

  Fly   295 SGFALKVQQQQRQKHMIRRRQP-----------AATLIQAVWRCY------------------AA 330
            :.|:...::|:||:..|:||:.           :..|..|..|..                  :|
Human   418 NNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSA 482

  Fly   331 DEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPP 395
            |::.:|.:.|...|.||     |..||    |.||        .:|.|.:...
Human   483 DDNHLSPSRWKWARKAL-----SETSS----NKSF--------ENKYQEVSQK------------ 518

  Fly   396 GSSRASTRYTRTIRDINASVENLEVVQN----------------GKSMNPSFSED---------- 434
             .|......|.:....:.|.:.||::.|                .|...||..|:
Human   519 -DSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCP 582

  Fly   435 ----SVAETTCLKNIKNSDASQPATLANCKLS-----------SSAGSL-AQFPDRNRDRDQDRR 483
                :||:|..:.::|::.:....|  :|...           .||..| .:||......::.:|
Human   583 QEQLAVAQTEVIVDMKSTSSIDSFT--SCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQR 645

  Fly   484 GHGEGEGDQAEEQAKAGGSRRNLTI---PVVLYGFLHGNFLGSTLSLRNPRVA------------ 533
            ..|......:.|:   |.:.|:.|:   ||.:...|..:  ||...|.:|..:
Human   646 ARGPPFLTLSREK---GPAARDGTLEYAPVDITVNLDAS--GSQCGLHSPLQSDNATDSPKSSLK 705

  Fly   534 ---PANDRDLEAGRDEDEVHKDTCQRSNTLPLPV--------------------------KP--- 566
               |...|.|:....|:.........|...||||                          :|
Human   706 GSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLG 770

  Fly   567 ---DSPSGSPGSGRTGRF-----FAAASH----FLETGFSSPNPIIDVANEED 607
               .:|...|..|.:.||     |..:|.    |.|         ||..::||
Human   771 TEVSAPCQGPSKGLSPRFPKQKLFPFSSRERRSFTE---------IDTGDDED 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	71/255 (28%)
		KCNQ_channel	<619..719	CDD:460954
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		BTB_POZ_KCNB2	19..145	CDD:349719
		Ion_trans	192..428	CDD:459842	70/253 (28%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..759	CDD:397541	58/324 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..534		9/55 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..571		3/21 (14%)
		FFAT. /evidence=ECO:0000269|PubMed:33124732	605..611		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..665		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..739		9/53 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	760..865		14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	892..911