DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and si:ch73-334d15.4

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_001336524.4	Gene:	si:ch73-334d15.4 / 796217	ZFINID:	ZDB-GENE-091204-184	Length:	430	Species:	Danio rerio

Alignment Length:	293	Identity:	77/293 - (26%)
Similarity:	124/293 - (42%)	Gaps:	55/293 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RRLQSRLYNFLERPRG--LHAIFYHVMVFLMVFTCLALSV----------------------FST 95
            |..|.:::...::|..  ...|...:.:|.::.:.:|.|:                      ||.
Zfish   144 RGWQRKIWALFDKPYSSVCARIIAIISLFFILLSIIAFSLWTLPSINSHQFLNAWASNSTDDFSR 208

  Fly    96 IKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILAS 160
            .:..|..|   |..:||:..|||..||..|..|         |..:|.|.   ..:::||.:||.
Zfish   209 TRPPEAQA---LDAVEIVCSIWFVFEFAIRAGS---------CPSKLWFF---INVMNIVDLLAL 258

  Fly   161 IVVLGMGTSG--QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAH--RQEL----ITTM 217
            .......:|.  .|||...|..:|..::||:.::.:.     :.|..|..|  |..|    |..:
Zfish   259 FPWFFRWSSNNFSVFALGFLHAMRCIRLLRVFKLMQH-----VFGVRVLTHTLRASLTSLCIVPL 318

  Fly   218 YIGFLGLIFASFLVY--MWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCAL 280
            .:....|||.:...:  :..||.....|:.....||.::||.|||||||:|:|.|||.:|..||:
Zfish   319 LLSICTLIFGTMFYFAELTHKDSYISSSSGLDGFWWALVTLTTVGYGDMLPVTRQGKCVAFLCAM 383

  Fly   281 LGISFFALPAGILGSGFALKVQQQQRQKHMIRR 313
            :|:....||..|:.:.| ||.....:.||.:.|
Zfish   384 VGVLLIVLPVPIIVNNF-LKFSSLVKTKHSMPR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	65/214 (30%)
		Ion_trans_2	221..295	CDD:285168	29/75 (39%)
		KCNQ_channel	<619..719	CDD:281513
si:ch73-334d15.4	XP_001336524.4	BTB	19..107	CDD:197585
		BTB_2	19..105	CDD:280393
		Ion_trans	217..400	CDD:278921	60/199 (30%)
		Ion_trans_2	319..402	CDD:285168	30/83 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900