DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcna1a

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_005163101.1	Gene:	kcna1a / 795942	ZFINID:	ZDB-GENE-110408-15	Length:	492	Species:	Danio rerio

Alignment Length:	504	Identity:	116/504 - (23%)
Similarity:	184/504 - (36%)	Gaps:	163/504 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52
            ||..:.| |:|         ..||:.:.||....|  .|.:|.|            |..|.....
Zfish    71 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPANVPLDMFSEEIKFYELGVEAME 125

  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95
            ::|                ..|.:::...|.|      ||:..:  .|||.|:......|.....
Zfish   126 KFREDEGFIREEERPLPEKEFQRQIWLLFEHPESSGPARGIAIV--SVMVILISIVIFCLETLPE 188

  Fly    96 IKEYEEDAVYIL----------------FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKF 144
            :||..|..:.|:                |.:|.|.:|||:.|...|.::         |..:..|
Zfish   189 LKEDPEGRIKIIGNTTYYYKPSILADPFFIIETLCIIWFSFELIVRFFA---------CPSKAAF 244

  Fly   145 VKRPFCIIDIVTILASIVVLGM----------GTSGQVFATSALRGLRFFQILRMVRMDRRGGTW 199
            .|.....||||.|:...:.||.          |...|..:.:.||.:|..::.|:.::.|.....
Zfish   245 FKNMMNTIDIVAIIPYFITLGTELAEEQDGKEGKGEQATSLAILRVIRLVRVFRIFKLSRHSKGL 309

  Fly   200 KLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDK-FSNFAQALWWGVITLCTVGYGD 263
            ::||..:.|..:||...::..|:|:|..|..||..|.:..:. ||:...|.||.|:::.||||||
Zfish   310 QILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEKESYFSSIPDAFWWAVVSMTTVGYGD 374

  Fly   264 MVPITWQGKLIASCCALLGISFFALPAGILGSGFAL---KVQQQQRQKHMIRRRQPAATLIQAVW 325
            |||:|..||::.|.||:.|:...|||..::.|.|..   :..:.:.|..::....|.
Zfish   375 MVPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLNVSNPN-------- 431

  Fly   326 RCYAADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGG 390
              .|:|.:|                  ||.|||            |:  .||:.::..|
Zfish   432 --IASDSNS------------------SRRSSS------------TV--SKSEYMEIDG------ 456

  Fly   391 VSKPPGSSRASTRYTRTIRDINASVENLE---------VVQNGKSMNPS 430
                               |||.|::|..         .:.|...:|.|
Zfish   457 -------------------DINNSIDNFREANLRTGNCTIPNQNCVNKS 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	66/234 (28%)
		Ion_trans_2	221..295	CDD:285168	32/74 (43%)
		KCNQ_channel	<619..719	CDD:281513
kcna1a	XP_005163101.1	BTB	36..130	CDD:197585	16/68 (24%)
		BTB_2	36..127	CDD:280393	15/65 (23%)
		Ion_trans	205..415	CDD:278921	64/218 (29%)
		Ion_trans_2	330..406	CDD:285168	32/75 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810