DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcnv1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_080476.2	Gene:	Kcnv1 / 67498	MGIID:	1914748	Length:	503	Species:	Mus musculus

Alignment Length:	356	Identity:	85/356 - (23%)
Similarity:	155/356 - (43%)	Gaps:	52/356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NYNRGTRRDVRYRRLQSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY 105
            ::::|....||     .:|::.||:|....|  ||..:.:..:..:.:.:::.|.  |.....:.
Mouse   186 DFSKGPCPTVR-----QKLWDILEKPGSSTAARIFGVISIIFVAVSIVNMALMSA--ELSWLNLQ 243

  Fly   106 ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCL-GRLKFVKRPFCIIDIVTILASIVVLGMGTS 169
            :|..:|.:.:.|||.||..|..          |: .|..|:::...|||::.||...:.|.:.:.
Mouse   244 LLEILEYVCISWFTGEFVLRFL----------CVKDRCHFLRKVPNIIDLLAILPFYITLLVESL 298

  Fly   170 GQVFATSALRG-------LRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFA 227
            .....|..|..       ||..:.|||:::.|.....:.||..:....:|:...:....:|:...
Mouse   299 SGSHTTQELENVGRLVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIF 363

  Fly   228 SFLVYMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAG 291
            |.:.|..|:.:.| .|::...|.||...::.||||||:.|.|..||::|..|.|.||...|||..
Mouse   364 STIEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIA 428

  Fly   292 ILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRAS 356
            |:...|:......:.::..:|:|:....|.:.:    |.|.: :||   |:..|
Mouse   429 IINDRFSACYFTLKLKEAAVRQREALKKLTKNI----ATDSY-ISV---NLRDV----------- 474

  Fly   357 SSFKHNTSFVARLPTIRRHKSQTIQTPGGGD 387
                :..|.:..|....|.::.| ::.||.|
Mouse   475 ----YARSIMEMLRLKGRERAST-RSSGGDD 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	57/213 (27%)
		Ion_trans_2	221..295	CDD:285168	28/74 (38%)
		KCNQ_channel	<619..719	CDD:281513
Kcnv1	NP_080476.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		BTB_POZ	44..163	CDD:365784
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..192		1/5 (20%)
		Ion_trans	212..438	CDD:366146	61/237 (26%)
		Selectivity filter. /evidence=ECO:0000250	395..400		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810