DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and Kcng4

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_080010.2	Gene:	Kcng4 / 66733	MGIID:	1913983	Length:	506	Species:	Mus musculus

Alignment Length:	292	Identity:	82/292 - (28%)
Similarity:	139/292 - (47%)	Gaps:	40/292 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RYRRLQSRLYNFLERPR-GLHA-IFYHVMVFLMVFTCLALSVFSTIKEYEED--------AVYIL 107
            |:.|..::|...:|.|: ||.. :|..:.|..:..|.::|.| ||:.::..:        ..|.:
Mouse   197 RWARSMNQLREMVEDPQSGLPGKVFACLSVLFVATTAVSLCV-STMPDFRAEEGKGECTRKCYYI 260

  Fly   108 FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMG----T 168
            |.:|.:.|.||::||        | .|:.....:.:|.:.|..:|||:.|....|.|.:.    .
Mouse   261 FVVESICVAWFSLEF--------C-LRFVQAPNKCQFFRGPLNVIDILAISPYYVSLAVSDESPE 316

  Fly   169 SGQVFATSA--------LRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLI 225
            :|:..::|:        ||.||..:||.::|:.|.....:.||..|....:|....|....:.:.
Mouse   317 AGERPSSSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCAREFGLLMLFLAVAVT 381

  Fly   226 FASFLVYMWEKDVND--KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFAL 288
            ..|.|||:.|.:...  :|::...:.||.:|::.|||||||||.:..|:::|....|.||...|.
Mouse   382 LFSPLVYVAENESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAF 446

  Fly   289 PAGILGSGFA-----LKVQQQQRQKHMIRRRQ 315
            ||..:...|:     ||.:|:|.|.. :||.|
Mouse   447 PATSIFHTFSHSYLELKREQEQVQAR-LRRLQ 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/231 (27%)
		Ion_trans_2	221..295	CDD:285168	26/75 (35%)
		KCNQ_channel	<619..719	CDD:281513
Kcng4	NP_080010.2	BTB_POZ	58..167	CDD:365784
		Ion_trans	219..463	CDD:366146	67/253 (26%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	416..421		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810