DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNQ and Kcnd3

DIOPT Version :10

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_001257891.1 Gene:Kcnd3 / 65195 RGDID:68394 Length:655 Species:Rattus norvegicus


Alignment Length:573 Identity:133/573 - (23%)
Similarity:218/573 - (38%) Gaps:174/573 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 NDIYAFYDI----------RGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQS 59
            :|..|||.|          ..||.:   .|.|:||::....|      ..|:.:...:.:|:...
  Rat   115 DDELAFYGILPEIIGDCCYEEYKDR---KRENAERLMDDNES------ENNQESMPSLSFRQTMW 170

  Fly    60 RLYNFLERPR--GLHAIFYHVMVFLMVFTCLALSVFSTIKEY---------------EEDAVYIL 107
            |.:   |.|.  .|..:||:|..|.     :|:||.:.:.|.               |..:| ..
  Rat   171 RAF---ENPHTSTLALVFYYVTGFF-----IAVSVITNVVETVPCGTVPGSKELPCGERYSV-AF 226

  Fly   108 FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQV 172
            |.::...|:.||:|:..||:::  .|||       :|::....|||:|.|:...:.|.|..:..|
  Rat   227 FCLDTACVMIFTVEYLLRLFAA--PSRY-------RFIRSVMSIIDVVAIMPYYIGLVMTNNEDV 282

  Fly   173 FATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFL 230
              :.|...||.|::.|:.:..|.....::||..:.:...||      |||       .:|||:.:
  Rat   283 --SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVM 339

  Fly   231 VYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGS 295
            .|..:.....||::...:.|:.::|:.|:|||||||.|..||:..|.|:|.|:...|||..::.|
  Rat   340 FYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVS 404

  Fly   296 GFALKVQQQQR-------QKHMIRRRQPAAT---------------------------------- 319
            .|:....|.||       :|..:.|.:.|.|                                  
  Rat   405 NFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTT 469

  Fly   320 -LIQA----VWRC--------YAADEHSVSVAT---------------WNIHRVALPSPPASRAS 356
             ||::    :..|        |..|:..:||.|               .|....::.:.|::|:.
  Rat   470 SLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSP 534

  Fly   357 SSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVV 421
            |...|  |.:......||.|..|             ..|.|:..:||.        .|::.|..:
  Rat   535 SLSSH--SGLTTTCCSRRSKKTT-------------HLPNSNLPATRL--------RSMQELSTI 576

  Fly   422 QNGKSMNPSF--SEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFP 472
            ....|..||.  |..|:       |:|..|..:|    |||.|....::...|
  Rat   577 HIQGSEQPSLTTSRSSL-------NLKADDGLRP----NCKTSQITTAIISIP 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 71/254 (28%)
KCNQ_channel <619..719 CDD:460954
Kcnd3NP_001257891.1 BTB_POZ_KCND3 6..143 CDD:349726 8/30 (27%)
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17 6..21
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17 70..78
Ion_trans 186..412 CDD:459842 69/248 (28%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 3/4 (75%)
DUF3399 468..563 CDD:463381 20/109 (18%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17 470..487 3/16 (19%)
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565 11/56 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..647 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

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