Protein Alignment KCNQ and Kcnq4

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001074611.1
• Gene: Kcnq4 / 60613
• MGIID: 1926803
• Length: 696
• Species: Mus musculus
• Alignment Length: 147
• Identity: 29/147 - (19%)
• Similarity: 50/147 - (34%)
• Gaps: 50/147 - (34%)

  Fly    49 YVFTAGDLHYRCHIPACENASTTALYTPDWLRDAVPFHGKPELPAKCDRYHVIPASDDFGCDAAR 113
            ::|.||.....|.   |..||..|.|..:|                          ..:..|..:
Mouse     4 FIFVAGISLALCQ---CGLASQLACYFANW--------------------------SQYRPDVGK 39

  Fly   114 FNQSAME--RCSEFVYA-------------DPTERTIVNDFNLTCEE--NLWKVTLVGTVHSIGQ 161
            :..|:::  .|:..:||             :..:.|:...||...:.  ||..:..|||: ::|
Mouse    40 YMPSSVDPHLCTHLIYAFSVINIKNKLATSEWNDETLYQSFNALKQSNPNLKTLLAVGTL-NLG- 102

  Fly   162 FVSLAMSGIISDRFGRR 178
              |...|.::|....||
Mouse   103 --STQFSRMVSTPQKRR 117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	22/124 (18%)
		KCNQ_channel	<619..719	CDD:460954
Kcnq4	NP_001074611.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/18 (28%)
		Ion_trans	99..331	CDD:459842	6/23 (26%)
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P56696	343..352
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..484
		KCNQ_channel	469..648	CDD:460954
		Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P51787	536..550
		C-terminal assembly domain (tetramerization). /evidence=ECO:0000250|UniProtKB:P56696	547..651
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..609