DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNQ and Kcnq4

DIOPT Version :9

Sequence 1:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster
Sequence 2:NP_001074611.1 Gene:Kcnq4 / 60613 MGIID:1926803 Length:696 Species:Mus musculus


Alignment Length:817 Identity:312/817 - (38%)
Similarity:410/817 - (50%) Gaps:202/817 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMSLLGKPL-----------------NYNRGTRR 50
            |..::.|...::..:|:.  |...|.|    |:.|||.||                 ...|.:..
Mouse    19 PRAELVALTAVQSEQGEA--GGGGSPR----RLGLLGSPLPPGAPLPGPGSGSGSACGGQRSSAA 77

  Fly    51 DVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVV 115
            ..||||||:.:||.|||||| .|..|||.:||:||:||.|||.|||:|::|.|...|..:|.:::
Mouse    78 QKRYRRLQNWVYNVLERPRG-WAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMI 141

  Fly   116 IWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRG 180
            :.|.:|:..|:||:||..||:|..||.:|.::|||:||.:..:||:.|:..||.|.:|||||||.
Mouse   142 VVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRS 206

  Fly   181 LRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNF 245
            :||.|||||||||||||||||||||||||.:||||..|||||.|||||||||:.|||.|..||::
Mouse   207 MRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSY 271

  Fly   246 AQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHM 310
            |.:||||.|||.|:||||..|.||.|:::|:..||||||||||||||||||||||||:|.||||.
Mouse   272 ADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHF 336

  Fly   311 IRRRQPAATLIQAVWRCYAAD-EHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRR 374
            .:||.|||.||||.||.|:.| ..:...|||..:...|||  ....:..|:|          |:|
Mouse   337 EKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPS--FRELALLFEH----------IQR 389

  Fly   375 HKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAET 439
            .::      ||.....|.:.|....|.:||...                               .
Mouse   390 ARN------GGLRPLEVRRAPVPDGAPSRYPPV-------------------------------A 417

  Fly   440 TCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRR 504
            ||         .:|.:.:.|...||...:   .||.|               .:..|.:.|.|::
Mouse   418 TC---------HRPGSASFCPGESSRMGI---KDRIR---------------ISSSQKRTGPSKQ 455

  Fly   505 NLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDS- 568
            :|..|                                                   |:|..|.| 
Mouse   456 HLAPP---------------------------------------------------PIPTSPSSE 469

  Fly   569 ---PSGSPGSGRTGRFFAAASHFLETGFSSP------NPIIDVANEEDEPRCTQLT-----NRHK 619
               .:.||...:....|...:.|..:....|      .|..:|| ||...:| :||     ...|
Mouse   470 QVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSAEEGPSEEVA-EEKSYQC-ELTVDDVMPAVK 532

  Fly   620 TAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQILGK------- 677
            |.||.:|.||:.||:|||||.|:|||||||:|||:|||:|:|||:|.|..|:|||:|:       
Mouse   533 TVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKT 597

  Fly   678 --QGSKA-KDVYA-SKISLASRVVKVERQVADIEEKLDILIKAYMEDRDRFL-----------AL 727
              :|.|. .|..| .:||:..||||||:||..||.|||:|:..|    .|.|           .:
Mouse   598 REKGDKGPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFY----SRCLRSGTSASLGTVQV 658

  Fly   728 PLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALS 764
            || ..|.|  .|..|.|:.|..    |.|..:|.::|
Mouse   659 PL-FDPDI--TSDYHSPVDHED----ISVSAQTLSIS 688

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
KCNQNP_788300.3 Ion_trans 100..305 CDD:278921 128/204 (63%)
Ion_trans_2 221..295 CDD:285168 50/73 (68%)
KCNQ_channel <619..719 CDD:281513 60/110 (55%)