Protein Alignment KCNQ and kcnd2

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001076336.1
• Gene: kcnd2 / 570188
• ZFINID: ZDB-GENE-041210-70
• Length: 630
• Species: Danio rerio
• Alignment Length: 558
• Identity: 130/558 - (23%)
• Similarity: 213/558 - (38%)
• Gaps: 116/558 - (20%)

  Fly    24 RPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPR--GLHAIFYHVMVFLMVFT 86
            |.|:|||....     :..|.|.....|:.:|....|.:   |.|.  .:..:||:|..|.:..:
Zfish   141 RENAERIQDDE-----ENDNNNDLVMPDLSFRESMWRAF---ENPHTSTMALVFYYVTGFFIAVS 197

  Fly    87 CLALSVFSTI---------KEYEEDAVYIL--FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLG 140
            .:| :|..|:         ||......|.|  |.::...|:.||:|:..||.::  .|||
Zfish   198 VMA-NVVETVPCGISLNRAKELSCGERYALAFFCLDTACVMIFTVEYLLRLIAA--PSRY----- 254

  Fly   141 RLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSV 205
              ||||....|||:|.|:...:.|.|..:..|  :.|...||.|::.|:.:..|.....::||..
Zfish   255 --KFVKSVMSIIDVVAIMPYYIGLVMTDNEDV--SGAFVTLRVFRVFRIFKFSRHSAGLRILGYT 315

  Fly   206 VYAHRQELITTMYIGFL-------GLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGD 263
            :.:...||      |||       .:|||:.:.|..:.....||::...|.|:.::|:.|:||||
Zfish   316 LKSCASEL------GFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGD 374

  Fly   264 MVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCY 328
            |||.|..||:..|.|:|.|:...|||..::.|.|:....|.||.:   :||....|
Zfish   375 MVPKTIMGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQSQRAE---KRRAQKKT--------- 427

  Fly   329 AADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSK 393
                        .:.|:.......:.|...:|.|...|.......:...|.:          |.|
Zfish   428 ------------RLARIRAAKSGGANAYLQYKRNGMLVDMEEEASKEAGQAL----------VCK 470

  Fly   394 PPGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLAN 458
              .:....|::...:..:.            |:.|..|.::...||:|::    ...::|:...:
Zfish   471 --ANPTFETQHHHLLHCLE------------KTTNHEFVDEQTYETSCME----VSLAKPSMSRS 517

  Fly   459 CKLSSSAGSLAQFPDRNRDRDQ----------DRRGHGEGEGDQAEEQAKAGGSRRNL------T 507
            ..:|||...|:....|...|..          .|||..:........:.....||.:|      |
Zfish   518 SSMSSSPHGLSSCCTRRNKRKSFNVPNSNMAGGRRGSIQELSTIQIRERPLSNSRSSLNAKFEET 582

  Fly   508 IPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
            :|  |..........:.:|:..|.|......||.:..|
Zfish   583 VP--LNSEEPSYITAAVISMPTPPVTTPEGVDLASSHD 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/213 (31%)
		Ion_trans_2	221..295	CDD:285168	29/80 (36%)
		KCNQ_channel	<619..719	CDD:281513
kcnd2	NP_001076336.1	Shal-type	3..28	CDD:288455
		BTB	42..139	CDD:197585
		BTB_2	42..131	CDD:280393
		Ion_trans	228..416	CDD:278921	65/204 (32%)
		Ion_trans_2	330..410	CDD:285168	29/79 (37%)
		DUF3399	444..548	CDD:288712	20/131 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810