Protein Alignment KCNQ and kcnq5b

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_697081.4
• Gene: kcnq5b / 568646
• ZFINID: ZDB-GENE-090312-178
• Length: 974
• Species: Danio rerio
• Alignment Length: 1044
• Identity: 351/1044 - (33%)
• Similarity: 468/1044 - (44%)
• Gaps: 324/1044 - (31%)

  Fly    34 RMSLLGKPLNYNRGT---RRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFST 95
            |:|||||||.|  ||   ||:.||||:|:.|||.|||||. .|..||..||::||.||.||||||
Zfish    72 RLSLLGKPLVY--GTQSGRRNARYRRIQNYLYNVLERPRS-WAFIYHAFVFVLVFGCLVLSVFST 133

  Fly    96 IKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILAS 160
            |.:::|.|...|..:|.::::.|.:|:..|:||:||..||:|..|||:|.::|||:|||:.::||
Zfish   134 IPDHQEMASQSLLILEFVMIVVFGLEYIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLIAS 198

  Fly   161 IVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLI 225
            :.|:..|:...:|||||||.|||.|||||||||||||||||||||||||.:||:|..|||||.||
Zfish   199 VAVVSAGSQSNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLVLI 263

  Fly   226 FASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            |:|||||:.||:.|..|:.:|.|||||.|||.|:||||..|.||.|:::::..||||||||.|||
Zfish   264 FSSFLVYLVEKEFNKDFATYADALWWGTITLTTIGYGDKTPKTWTGRMLSAGFALLGISFFTLPA 328

  Fly   291 GILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRA 355
            ||||||||||||:|.||||..:||.|||.|||.|||.|||||:|||||||..|..||
Zfish   329 GILGSGFALKVQEQHRQKHFEKRRNPAACLIQCVWRSYAADENSVSVATWKPHLKAL-------- 385

  Fly   356 SSSFKHNTSFVARLPTIR-RHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLE 419
                 |..|     ||.: :.:|.|.|.....|...::.|.|.|..|.:.:.|.|
Zfish   386 -----HTCS-----PTKKDQGESATSQKLSFKDRVRMASPRGQSIKSRQTSVTDR---------- 430

  Fly   420 VVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQDR-- 482
                 :|.....|               :|.|.||     |:..|    ..|.||.|.|...|
Zfish   431 -----RSPGAEIS---------------TDGSSPA-----KVQKS----WSFNDRTRFRPSLRLK 466

  Fly   483 ---RGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGR 544
               |...|||.              |:|:                                :...
Zfish   467 SQSRSTPEGEA--------------NVTV--------------------------------DEAF 485

  Fly   545 DEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEP 609
            ||...|.|                                                  .:.||.|
Zfish   486 DEKGCHCD--------------------------------------------------MSVEDLP 500

  Fly   610 RCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQI 674
            ...      ||.||.:|.:|:.||::||||.|:|||||||:|||:|||:|:|.|:|.|..|:|||
Zfish   501 SAL------KTVIRAVRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQI 559

  Fly   675 LGK----QGSKAKDVYAS------KISLASRVVKVERQVADIEEKLDILIKAYMEDRDR------ 723
            ||:    ...|.::...|      .:|:..||.||||||..||.|||.|:..|.:...:
Zfish   560 LGRGQMPVDKKVREKLLSDGDILEDVSMLGRVCKVERQVQSIESKLDSLLDIYRQVLQKGSSTAL 624

  Fly   724 -FLALPLP--------------------AKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHP 767
             |.:|| |                    |.....||..:|               .|...|.:.|
Zfish   625 TFSSLP-PFGLEENSDYQSTVLSKDLSCASQVSQSICGNH---------------PRALQLILAP 673

  Fly   768 EQV---------TTTPLLNPSA-----------PDSSELRSLTATQTPTTTTDAIATQTPM---- 808
            .::         |::|.|||::           |.:..|...:|..:|:...:|.:....:
Zfish   674 NELMNLNQNNSTTSSPGLNPASASPFNLSTFQVPSTPSLECPSAQGSPSQILNANSFHCSIGHFP 738

  Fly   809 -----PPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEP--YSK 866
                 ||.:..|.|       :.|||.:...|...              ..|:..:.|:|  |:|
Zfish   739 SVGQPPPPLSSTTT-------SKYQLSTVPSQAGH--------------ARSMGPTRSDPADYAK 782

  Fly   867 QEQRITIPDEGADS-----LDSSAKPTPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDI 926
            ...|....|.|.:|     |....:|:..:.|                         :|.....:
Zfish   783 SCFRGVGIDLGLNSSMICKLQQKNRPSAKEDS-------------------------SWRRHISL 822

  Fly   927 GVEVDVD--------ADADGDCDE--------STEDTALLQCATRTAIVITPISPVSSAHNLQQL 975
            ..||::|        |...|.|..        |.:|  |:|.|.....|.|..|..|.:.::...
Zfish   823 DSEVEMDPLAPVSPLAPVQGQCSGDRGLGKSLSVQD--LIQPALEGVGVDTHSSQASFSTSISSS 885

  Fly   976 NDQT 979
            .|.:
Zfish   886 QDSS 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	124/204 (61%)
		Ion_trans_2	221..295	CDD:285168	46/73 (63%)
		KCNQ_channel	<619..719	CDD:281513	55/109 (50%)
kcnq5b	XP_697081.4	Ion_trans	145..343	CDD:278921	122/197 (62%)
		Ion_trans_2	259..333	CDD:285168	46/73 (63%)
		KCNQ_channel	443..625	CDD:281513	78/292 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1323
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1321
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24976
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.860