DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcnv2b

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001122212.1	Gene:	kcnv2b / 567780	ZFINID:	ZDB-GENE-060526-28	Length:	527	Species:	Danio rerio

Alignment Length:	377	Identity:	92/377 - (24%)
Similarity:	148/377 - (39%)	Gaps:	83/377 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DPD--NDIYAFY-----------------------DIR-GYKGKCRPGRPNSERILQPRMSLLGK 40
            |||  |.|:.||                       .:| .|..:|      ...:|:.:...|.:
Zfish   137 DPDVFNSIFNFYRTGVLWIKDELCPRNFLEEISYWGVRIKYSQRC------CRILLEEKNDELCE 195

  Fly    41 PLNYNRGTRRDVRYRRL----------QSR--LYNFLERP-RGLHAIFYHVMVFLMVFTCLALSV 92
            .|...:...|::.....          :||  |::|:|:| ..:.|....|...:.|...|....
Zfish   196 QLKVQKELERELEIEENEEAFDDMILGESRRSLWDFMEKPFSSIPAKLMAVTSSMFVLISLVTMT 260

  Fly    93 FSTIKEYE----EDAVYILFRMEILVVIWFTMEFGARLWSSG--CRSRYQGCLGRLKFVKRPFCI 151
            .||::|.|    |...|..| :|.|.:.:||:|:..|:.|:.  ||           |.|.....
Zfish   261 LSTVEEMENIESEGKNYGEF-VENLCITFFTIEYLLRVISTPDICR-----------FFKSMLNA 313

  Fly   152 IDIVTILASIVVL---------------GMGTSGQVFAT-SALRGLRFFQILRMVRMDRRGGTWK 200
            :|::.||..|:..               .|.|.|||... ..||.:|..:|.|::::.|.....:
Zfish   314 VDLMAILPQILQFMLENFETFGSRNQSADMETVGQVGKVGQVLRIMRLLRIFRVLKLARHSTGLR 378

  Fly   201 LLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDV-NDKFSNFAQALWWGVITLCTVGYGDM 264
            ..|..:....|::........:|:...|.:||..|.|| ...|::...:.||..:::.|||||||
Zfish   379 AFGFTLKQCYQQVGCLFLFIAMGIFTFSAMVYSVEYDVPKTNFTSIPHSWWWASVSISTVGYGDM 443

  Fly   265 VPITWQGKLIASCCALLGISFFALPAGILGSGFA---LKVQQQQRQKHMIRR 313
            .|.|..|::.|..|...||....||..||.:.|:   .|::..:...||..|
Zfish   444 YPETLLGRIFAFGCISFGIILNGLPISILFNKFSDYYAKLKSHECPSHMKNR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/230 (27%)
		Ion_trans_2	221..295	CDD:285168	28/74 (38%)
		KCNQ_channel	<619..719	CDD:281513
kcnv2b	NP_001122212.1	BTB	82..173	CDD:295341	7/35 (20%)
		BTB	84..187	CDD:197585	10/55 (18%)
		Ion_trans	279..484	CDD:278921	59/216 (27%)
		Ion_trans_2	409..478	CDD:285168	27/68 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810