DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and kcnb2b

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_695259.4	Gene:	kcnb2b / 566883	ZFINID:	ZDB-GENE-091113-38	Length:	831	Species:	Danio rerio

Alignment Length:	658	Identity:	144/658 - (21%)
Similarity:	242/658 - (36%)	Gaps:	207/658 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFRMEIL 113
            :.:|:..||:|....|  |...:.:..:|.:.:|||: :|:.|.:....:       .|..:|.:
Zfish   177 RKKLWELLEKPSSSVAAKILAIISILFIVLSTVALSL-NTLPELQVTDEFGQANDNPQLAHVEAV 240

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||||:..|..||.         .:.||.|.|..:||::.||...|.:.:..|.
Zfish   241 CIAWFTMEYLLRFLSSP---------NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQN 296

  Fly   171 -----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFL 230
                 |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.|
Zfish   297 VRRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL 353

  Fly   231 VYMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            |:..|||.: .||::...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.
Zfish   354 VFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIV 418

  Fly   295 SGFALKVQQQQRQKHMIRRRQP-----------AATLIQAVWRCY--------------AADEHS 334
            :.|:...::|:||:..|:||:.           :..|..|..|..              ..|.|
Zfish   419 NNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELMDVTVEKSDDKRLTDNH- 482

  Fly   335 VSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSR 399
            :|.:.|.|       |..:.:.:|.:   ||..:.|                           :.
Zfish   483 LSPSRWGI-------PQRTSSDTSLR---SFDKKFP---------------------------NS 510

  Fly   400 ASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTC------------LKNIKNSDASQ 452
            .|..|.......:.:.:|||.:.|..:...|||:.|.:.:|.            :|.:..:...|
Zfish   511 GSQEYVHMPSPQHLNAQNLEEMYNQMTKTQSFSDLSTSNSTQPAVVSKHEVELEMKEVPTAVKQQ 575

  Fly   453 P--ATLANCKLSSSAGSL----AQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVV 511
            |  .|:.:.:..||..|.    |:|                |:|::|             |.|
Zfish   576 PKERTITDVRSISSVDSFASCTAEF----------------GQGEKA-------------TTP-- 609

  Fly   512 LYGFLHGNFLGSTLSLRNPRVAP------ANDRDLEAGRDEDEVHKDTCQ--------RSN---T 559
                   :........|.|:|:|      ....||....:...|::||..        ||:   |
Zfish   610 -------SHTAEQFQQRLPKVSPQLHLGQLTPSDLSPEENSGIVNRDTDDLNEFVENIRSSIRGT 667

  Fly   560 LPLPVK----------PDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEP--RCT 612
            .|:..|          .|:|...|.:                  |||..|.:...|:|.|  .|:
Zfish   668 NPIKAKGLKVNFIETPEDAPLTPPNT------------------SSPQDINNSLLEDDSPEGECS 714

  Fly   613 QLTNRHKT 620
            .|.:..:|
Zfish   715 PLCSDSET 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	61/225 (27%)
		Ion_trans_2	221..295	CDD:285168	29/74 (39%)
		KCNQ_channel	<619..719	CDD:281513	1/2 (50%)
kcnb2b	XP_695259.4	BTB	37..143	CDD:197585
		BTB_2	37..136	CDD:280393
		Ion_trans	231..429	CDD:278921	61/214 (29%)
		Ion_trans_2	342..423	CDD:285168	30/80 (38%)
		Kv2channel	480..706	CDD:281514	56/319 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810