Protein Alignment KCNQ and Kcnd3

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_064315.1
• Gene: Kcnd3 / 56543
• MGIID: 1928743
• Length: 655
• Species: Mus musculus
• Alignment Length: 573
• Identity: 133/573 - (23%)
• Similarity: 218/573 - (38%)
• Gaps: 174/573 - (30%)

  Fly     5 NDIYAFYDI----------RGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQS 59
            :|..|||.|          ..||.:   .|.|:||::....|      ..|:.:...:.:|:...
Mouse   115 DDELAFYGILPEIIGDCCYEEYKDR---KRENAERLMDDNDS------ENNQESMPSLSFRQTMW 170

  Fly    60 RLYNFLERPR--GLHAIFYHVMVFLMVFTCLALSVFSTIKEY---------------EEDAVYIL 107
            |.:   |.|.  .|..:||:|..|.     :|:||.:.:.|.               |..:| ..
Mouse   171 RAF---ENPHTSTLALVFYYVTGFF-----IAVSVITNVVETVPCGTVPGSKELPCGERYSV-AF 226

  Fly   108 FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQV 172
            |.::...|:.||:|:..||:::  .|||       :|::....|||:|.|:...:.|.|..:..|
Mouse   227 FCLDTACVMIFTVEYLLRLFAA--PSRY-------RFIRSVMSIIDVVAIMPYYIGLVMTNNEDV 282

  Fly   173 FATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFL 230
              :.|...||.|::.|:.:..|.....::||..:.:...||      |||       .:|||:.:
Mouse   283 --SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVM 339

  Fly   231 VYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGS 295
            .|..:.....||::...:.|:.::|:.|:|||||||.|..||:..|.|:|.|:...|||..::.|
Mouse   340 FYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVS 404

  Fly   296 GFALKVQQQQR-------QKHMIRRRQPAAT---------------------------------- 319
            .|:....|.||       :|..:.|.:.|.|
Mouse   405 NFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEQMGKTT 469

  Fly   320 -LIQA----VWRC--------YAADEHSVSVAT---------------WNIHRVALPSPPASRAS 356
             ||::    :..|        |..|:..:||.|               .|....::.:.|::|:.
Mouse   470 SLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSP 534

  Fly   357 SSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVV 421
            |...|  |.:......||.|..|             ..|.|:..:||.        .|::.|..:
Mouse   535 SLSSH--SGLTTTCCSRRSKKTT-------------HLPNSNLPATRL--------RSMQELSTL 576

  Fly   422 QNGKSMNPSF--SEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFP 472
            ....|..||.  |..|:       |:|..|..:|    |||.|....::...|
Mouse   577 HIQGSEQPSLTTSRSSL-------NLKADDGLRP----NCKTSQITTAIISIP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/211 (30%)
		Ion_trans_2	221..295	CDD:285168	28/80 (35%)
		KCNQ_channel	<619..719	CDD:281513
Kcnd3	NP_064315.1	Interaction with KCNIP2. /evidence=ECO:0000250	2..20
		BTB_POZ_KCND3	6..143	CDD:349726	8/30 (27%)
		Ion_trans	182..412	CDD:366146	70/252 (28%)
		Selectivity filter. /evidence=ECO:0000250	367..372		3/4 (75%)
		DUF3399	442..563	CDD:371777	20/135 (15%)
		Mediates dendritic targeting. /evidence=ECO:0000250	472..487		2/14 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..565		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..655		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810