DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcns3a

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001122196.1	Gene:	kcns3a / 565375	ZFINID:	ZDB-GENE-080723-45	Length:	499	Species:	Danio rerio

Alignment Length:	303	Identity:	77/303 - (25%)
Similarity:	137/303 - (45%)	Gaps:	45/303 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 MSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFST 95
            :|...|.|....||    :|...:.||::..|:   |...:.|:|...:|.:.:   :|:.:.|.
Zfish   154 LSAFDKDLEKFEGTWCAEKRKELWLRLENPGYS---RSAKILAVFSLSVVLISI---IAMCIHSM 212

  Fly    96 IKEYEEDAVY------ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDI 154
            .:.:::||..      :|...|...|:||::||..||..:.|..         ||:.....:||.
Zfish   213 PEFHQKDANEKEVENPVLDVFETFCVLWFSLEFIVRLVVTPCLR---------KFICNALNMIDF 268

  Fly   155 VTILASIVVLG-----------MGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYA 208
            .:|:.....|.           :...|:|  ...||.:|.|:||::.|  ...|...|..::.::
Zfish   269 ASIVPFYATLAFEKVDPEESEELENVGRV--VQILRLMRIFRILKLAR--HSVGLRSLGATLRHS 329

  Fly   209 HRQELITTMYIGFLGLIFASFLVYMWEK-DVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGK 272
            :.:..:..:::. :|:...|.|:|..|: |...:........||..|::.||||||..|:|..||
Zfish   330 YHEVGLLILFLS-VGISIFSVLIYFVEREDHESELQTIPVGWWWATISMTTVGYGDTYPVTLPGK 393

  Fly   273 LIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQ 315
            ||.:.|.:.|:...|||..|:.:.|:   :..||||.::...|
Zfish   394 LIGTLCIICGLLVVALPISIIFNKFS---KYYQRQKALVESDQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	57/222 (26%)
		Ion_trans_2	221..295	CDD:285168	27/74 (36%)
		KCNQ_channel	<619..719	CDD:281513
kcns3a	NP_001122196.1	BTB_2	17..116	CDD:308049
kcns3a	NP_001122196.1	Ion_trans	189..426	CDD:306908	64/256 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810