DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and KCNQ5

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001153605.1	Gene:	KCNQ5 / 56479	HGNCID:	6299	Length:	951	Species:	Homo sapiens

Alignment Length:	1024	Identity:	359/1024 - (35%)
Similarity:	478/1024 - (46%)	Gaps:	286/1024 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RMSLLGKPLNY--NRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTI 96
            |||||||||:|  ::..||:|:|||:|:.|||.|||||| .|..||..|||:||.||.|||||||
Human    86 RMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLERPRG-WAFIYHAFVFLLVFGCLILSVFSTI 149

  Fly    97 KEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASI 161
            .|:.:.|...|..:|.::::.|.:||..|:||:||..||:|..|||:|.::|||:||.:.::|||
Human   150 PEHTKLASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASI 214

  Fly   162 VVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
            .|:...|.|.:|||||||.|||.|||||||||||||||||||||||||.:||||..|||||.|||
Human   215 AVVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIF 279

  Fly   227 ASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAG 291
            :|||||:.|||.|.:||.:|.|||||.|||.|:||||..|:||.|:|:::..|||||||||||||
Human   280 SSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAG 344

  Fly   292 ILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALP--SP---- 350
            |||||||||||:|.||||..:||.|||.|||.|||.|||||.|||:|||..|..||.  ||
Human   345 ILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKE 409

  Fly   351 PASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASV 415
            ....:||.|..|...:.|:.|.|: :||.:...   :...::.|.|.|         |:...|||
Human   410 QGEASSSKFCSNKQKLFRMYTSRK-QSQKLSFK---ERVRMASPRGQS---------IKSRQASV 461

  Fly   416 ENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQ 480
                    |...:|  |.|..||.:..|..|:                     ..|.||.|.|
Human   462 --------GDRRSP--STDITAEGSPTKVQKS---------------------WSFNDRTRFR-- 493

  Fly   481 DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
                                                      .:|.|::.:..|..|.|...|.|
Human   494 ------------------------------------------PSLRLKSSQPKPVIDADTALGTD 516

  Fly   546 EDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANEEDEPR 610
             |...:..||                                            .||:.|:
Human   517 -DVYDEKGCQ--------------------------------------------CDVSVED---- 532

  Fly   611 CTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLRLDQIL 675
               ||...||.||.||.:|:.||:|||||.|:|||||||:|||:|||:|:|.|:|.|..|:||||
Human   533 ---LTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQIL 594

  Fly   676 GK----QGSKAKDVYASK------ISLASRVVKVERQVADIEEKLDILIKAY------------- 717
            ||    ...|:::...::      :|:..||||||:||..||.|||.|:..|
Human   595 GKGQITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALA 659

  Fly   718 --------------------MEDRD-----------------------RFLALP--------LPA 731
                                ::.:|                       :|:..|        ...
Human   660 LASFQIPPFECEQTSDYQSPVDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYAL 724

  Fly   732 KPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSELRSLTATQTPT 796
            .|.:|| ..:..|:..:...|:       ||.:....|:.|.|  .|:||        |..|.|
Human   725 SPTMHS-QATQVPISQSDGSAV-------AATNTIANQINTAP--KPAAP--------TTLQIP- 770

  Fly   797 TTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDV---FMTELENRTKKRVTLSLHR 858
                      |..|.::|.   .:...|:....|.: :..:||   .:...||....:..|:..|
Human   771 ----------PPLPAIKHL---PRPETLHPNPAGLQ-ESISDVTTCLVASKENVQVAQSNLTKDR 821

  Fly   859 STSEPYSKQEQRITIPDEGADSLDSSAKPTPPDSSIILIDEYEDFEEEDLNCE----------GE 913
            |..:.:          |.|.::|.|.....|.|....|..:......|:||.:          |.
Human   822 SMRKSF----------DMGGETLLSVCPMVPKDLGKSLSVQNLIRSTEELNIQLSGSESSGSRGS 876

  Fly   914 MDHFPTWE------IDSDIGVEVDVDADADGDCDESTEDTALLQCATRT 956
            .|.:|.|.      .|.::|.| :.:.|......:...:.|....:.||
Human   877 QDFYPKWRESKLFITDEEVGPE-ETETDTFDAAPQPAREAAFASDSLRT 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	130/204 (64%)
		Ion_trans_2	221..295	CDD:285168	50/73 (68%)
		KCNQ_channel	<619..719	CDD:281513	57/142 (40%)
KCNQ5	NP_001153605.1	Ion_trans	160..358	CDD:278921	129/197 (65%)
		Ion_trans_2	274..348	CDD:285168	50/73 (68%)
		Selectivity filter. /evidence=ECO:0000250	311..316		3/4 (75%)
		KCNQ_channel	472..659	CDD:281513	81/303 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..697		1/22 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..938		6/31 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1392
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51484
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860