DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcng2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_690900.2	Gene:	kcng2 / 562421	ZFINID:	ZDB-GENE-100701-1	Length:	546	Species:	Danio rerio

Alignment Length:	300	Identity:	85/300 - (28%)
Similarity:	130/300 - (43%)	Gaps:	55/300 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GTRRDVRYRRLQSRLYNFLERPR-GLHA-IFYHVMVFLMVFTC--LALSVFSTIKEYEE-----D 102
            |:..:.|.......|.:.:|.|. |:.. ||..:.|..:..|.  |.:|....::|.||     .
Zfish   209 GSPEEGRLSGCMHSLRDMVENPHSGIPGKIFACLSVVFVAITAVTLCVSTMPDLREEEERGECSQ 273

  Fly   103 AVYILFRMEILVVIWFTMEFGARL--WSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVL- 164
            ..|.:|.:|.:.|.||::||..|.  ..|.|           .|::.|..|||:|.||...:.|
Zfish   274 RCYNIFVLETVCVGWFSLEFLLRFIQTQSKC-----------TFLRTPLNIIDVVAILPYYITLI 327

  Fly   165 -----------GMGTS-----GQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQEL 213
                       |.|.:     |.|.  ..||.||.|.::|:.|......|   ||..|....:|.
Zfish   328 VDSMSVGDRPAGSGNNYLEKVGLVL--RVLRALRIFYVMRLARHSLGLQT---LGLTVRRCTREF 387

  Fly   214 ITTMYIGFLGLIFASF--LVYMWEKDVNDK--FSNFAQALWWGVITLCTVGYGDMVPITWQGKLI 274
              .:.:.||.:..|.|  ||::.|.::..|  |::...:.||.||::.|||||||||.:..|:::
Zfish   388 --GLLLLFLCVAMALFSPLVFLAESELGAKQEFTSIPGSYWWAVISMTTVGYGDMVPRSIPGQVV 450

  Fly   275 ASCCALLGISFFALPAGILGSGFA-----LKVQQQQRQKH 309
            |....|.||...|.|...:...|:     ||.:|.:..:|
Zfish   451 ALSSILSGILLMAFPVTSIFHTFSRSYLELKEEQNRATRH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	71/237 (30%)
		Ion_trans_2	221..295	CDD:285168	29/77 (38%)
		KCNQ_channel	<619..719	CDD:281513
kcng2	XP_690900.2	BTB	72..172	CDD:197585
		BTB_2	73..171	CDD:280393
		Ion_trans	273..481	CDD:278921	66/225 (29%)
		Ion_trans_2	<416..475	CDD:285168	22/58 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810