Protein Alignment KCNQ and kcng4a

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001103499.1
• Gene: kcng4a / 561003
• ZFINID: ZDB-GENE-050419-11
• Length: 538
• Species: Danio rerio
• Alignment Length: 391
• Identity: 94/391 - (24%)
• Similarity: 161/391 - (41%)
• Gaps: 99/391 - (25%)

  Fly    51 DVRYRRLQSRLYNFLERPRG-----LHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAV-----Y 105
            :.|||:..::|.:.:|.|:.     :.|.|..:||.:.|.: |.:|....::|.|...|     .
Zfish   195 ETRYRKFMNQLRDMVENPQSGVPGKVFACFSVLMVAITVIS-LCISTMPDLREEENRGVCSQKCQ 258

  Fly   106 ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL---ASIVV---- 163
            .:|.:|.:.|.||::||         ..|:.....:|:|::.|..|||.:.||   .|:||
Zfish   259 HMFIIETVCVAWFSLEF---------LLRFVQARSKLQFLRGPLNIIDAMAILPYYVSLVVDEKP 314

  Fly   164 ----------------LGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQE 212
                            ||:          .||.||..:||.::|:.|.....:.||..|....:|
Zfish   315 NDENERPSGGKGYLDKLGL----------VLRILRALRILYVMRLARHSLGLQTLGLTVRRSTRE 369

  Fly   213 LITTMYIGFLGLIFASFLVYMWEKDVN--DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIA 275
            ....:....:.:...|.||::.|.::.  ..||:...:.||.:|::.|||||||||.:..|:::|
Zfish   370 FGLLLLFLCVAVTLFSPLVHLAESELTGVQDFSSIPASYWWAIISMTTVGYGDMVPRSIPGQVVA 434

  Fly   276 SCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATW 340
            ....|.||...|.||..:...|:...|:.:::...:.:.:           |.||     :.||.
Zfish   435 LSSILSGILIMAFPATSIFHMFSRSYQELKQEHDRLFKEE-----------CAAA-----AAATT 483

  Fly   341 NIHR------VALPSP-----PASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKP 394
            .:..      ||.|.|     |.:..:.|.: :.|.:.                .||:..|.:|.
Zfish   484 GLEEEQDGGWVAFPPPRLVLTPDTETAGSCE-DLSLLG----------------NGGETSGNNKH 531

  Fly   395 P 395
            |
Zfish   532 P 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/234 (27%)
		Ion_trans_2	221..295	CDD:285168	26/75 (35%)
		KCNQ_channel	<619..719	CDD:281513
kcng4a	NP_001103499.1	BTB	63..169	CDD:197585
		BTB_2	63..160	CDD:280393
		Ion_trans	261..464	CDD:278921	61/221 (28%)
		Ion_trans_2	376..458	CDD:285168	27/81 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810