DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcnc3a

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_009297818.1	Gene:	kcnc3a / 559096	ZFINID:	ZDB-GENE-100901-1	Length:	666	Species:	Danio rerio

Alignment Length:	459	Identity:	106/459 - (23%)
Similarity:	182/459 - (39%)	Gaps:	93/459 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 VMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFR---------MEILVVIWFTMEFGARL 126
            :::.:..|.......|:||....|:...       ::|.         :|.:.|:|||:|...|:
Zfish   218 ILISISTFCLETHEAFNTIYNKTENVTVGNVTREEVVFEVVTDNWLTYVEGVCVVWFTIEVFTRV 282

  Fly   127 WSSGCRSRYQGCLGRLKFVKRPFCIIDIVTIL---ASIVVLGMGTSGQVFATSALRGLRFFQILR 188
            ..         |..:.:|.|....|||.|.||   ..:.:.|:.:.........||.:||.:|||
Zfish   283 IF---------CPDKAEFFKSSLNIIDFVAILPFYLEMALSGLSSKAAKDVLGFLRVVRFVRILR 338

  Fly   189 MVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEK---DVND-------KFS 243
            :.::.|.....::||..:.|...|.:..:....||::..:.::|..|:   |.:|       .|.
Zfish   339 IFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDPTASAHTAFK 403

  Fly   244 NFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL----GSGFALKVQQQ 304
            |.....||.|:|:.|:|||||.|.||.|.|:.:.|||.|:...|:|..::    |..::|.:.:|
Zfish   404 NIPIGFWWAVVTMTTLGYGDMYPETWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQ 468

  Fly   305 ----QRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRV--------------ALPSPP 351
                ::.||:.|..||.:.       .|...: ::::||.:.||:              |...|.
Zfish   469 KLPKKKNKHIPRAPQPGSP-------NYCKPD-ALAMATASPHRIMGNVLGSMVVSGSMAGDCPL 525

  Fly   352 A-------SRASSSFKHNTSFVA----RLPTIRRHKSQTIQTP--GG-GDGGGVSKPPGSSRAST 402
            |       :||.|....:.:..|    ..|||.:......::|  || |.|.|..:.|.......
Zfish   526 AQEEIIEINRADSKQNGDAANAALANEDCPTIDQVLGPDDRSPATGGLGTGTGRERYPHDRACFL 590

  Fly   403 RYTRTIRDINASVEN---LEVVQNGKSMNPSFSEDS--------VAETTCLKNIKNSDASQPATL 456
            ..|...|..:::|..   :..|..|...:.|.:..|        :...|.:.|........|..|
Zfish   591 LSTGEFRTTDSNVRKGCVVSCVSAGYEKSRSLNNISGMTGAPLRLTPITPINNPPYEPYESPGPL 655

  Fly   457 ANCK 460
            ..|:
Zfish   656 RRCR 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/241 (26%)
		Ion_trans_2	221..295	CDD:285168	29/87 (33%)
		KCNQ_channel	<619..719	CDD:281513
kcnc3a	XP_009297818.1	Potassium_chann	1..29	CDD:314363
		BTB_2	38..132	CDD:308049
		Ion_trans	207..465	CDD:306908	66/255 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810