DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcns3b

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001032460.1	Gene:	kcns3b / 558674	ZFINID:	ZDB-GENE-051120-78	Length:	424	Species:	Danio rerio

Alignment Length:	311	Identity:	79/311 - (25%)
Similarity:	147/311 - (47%)	Gaps:	59/311 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NSERILQPRMSLLGKPLNYNRGTR-RDVRYRRLQSRLYNFLERP------RGLHAIFYHVMVFLM 83
            :|:......:|:..:.|..:.|.| .|||     ..::..||.|      ||:.|    |.|.::
Zfish   136 SSKNASSGEISVTSEDLWKSEGMRCSDVR-----KLMWETLEDPQHSRCSRGVAA----VSVLVI 191

  Fly    84 VFTCLALSVFSTIK-EYEEDAVY-ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVK 146
            :.:.||:.|.|..: .|:.|..: :|..:|:..:::|::||..|:.::.         ..|:|:.
Zfish   192 LISILAMCVHSLPEFRYQTDGEHSVLDSVELFCIVFFSVEFFLRVIAAP---------QPLRFLG 247

  Fly   147 RPFCIIDIVTILASIVVL-----------------GMGTSGQVFATSALRGLRFFQILRMVR--- 191
            .|..:||:.:||...:.|                 .||...||     ||.:|.|::|::.|
Zfish   248 NPLNMIDVASILPFYITLAVERLDEEDKEENQSLVNMGRVVQV-----LRLMRSFRVLKLARHSE 307

  Fly   192 -MDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVIT 255
             |...|.|  |:..........|..|:.|.|    |::|:.|..:::.:.:.|:.....|||:|:
Zfish   308 GMRAFGET--LMNCQCEVGLLVLFITVGISF----FSTFIYYTEKEEASSQLSSIPICWWWGIIS 366

  Fly   256 LCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQR 306
            :.||||||:.|:|..|:::|:.|.|.|:...:||..|:.:.|:...::.::
Zfish   367 MTTVGYGDVYPLTVAGRIVATVCILCGLLVISLPITIIMNNFSKYFEKNRK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	58/226 (26%)
		Ion_trans_2	221..295	CDD:285168	25/73 (34%)
		KCNQ_channel	<619..719	CDD:281513
kcns3b	NP_001032460.1	BTB	17..117	CDD:197585
		BTB_2	17..116	CDD:280393
		Ion_trans	205..414	CDD:278921	59/228 (26%)
		Ion_trans_2	329..410	CDD:285168	28/84 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900