DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and kcnf1a

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001076280.1	Gene:	kcnf1a / 557280	ZFINID:	ZDB-GENE-041001-217	Length:	494	Species:	Danio rerio

Alignment Length:	355	Identity:	98/355 - (27%)
Similarity:	158/355 - (44%)	Gaps:	53/355 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RYRRLQSRLYNFLERPR-GLHAIFYHVMVFLMVFTCLALSVFSTIKE--YEEDAVYI-----LFR 109
            |.:|.|:.|:..:|:|. .:.|....|:.|:.:.....:....||.|  .::|..::     |..
Zfish   163 RSQRCQTFLWKLMEKPESSVAARVIAVVSFVFILLSSVVMCVGTIPELQVQDDEGHLTEHPTLEA 227

  Fly   110 MEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVL---GMGTSGQ 171
            :|...:||||:|:..||.||.         .:|.||.....|||.:.|:...|||   .:||:..
Zfish   228 IETACIIWFTVEYVLRLASSS---------SKLHFVFSFLNIIDFLAIMPFYVVLILTHLGTAMM 283

  Fly   172 VFAT--SALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQEL-ITTMYIGFLGLIFASFLVYM 233
            ..|.  .|::.||..:|.|:.::.|.....:.|...:.:..:|| :..||:. :|:...|.|.|.
Zfish   284 ELANVQQAVQALRIMRIARIFKLARHSSGLQTLTFALKSSLKELGLLLMYMS-VGIFLFSALGYT 347

  Fly   234 WEKD-VNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297
            .|:. ....|::..|:.||.:||:.||||||:.|.|..|:..|:...|.|:...|||...:.:.|
Zfish   348 MEQSHPETMFTSIPQSFWWAIITMTTVGYGDIYPKTTLGRCNAAVSFLCGVIAIALPIHPIINNF 412

  Fly   298 ALKVQQQQR-----QKHMI-----RRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPA 352
            .: |..:||     .||.|     |.|:.|....:|..|..:.|..|:    |:
Zfish   413 VI-VYSKQRVLETAAKHEIELMALRAREEAQECPEAERRAASVDSSSM----WD----------- 461

  Fly   353 SRASSSFKHNTSFVARL-PTIRRHKSQTIQ 381
             .|:.|...:.||:..| .|....|:|..|
Zfish   462 -SAAVSASQSDSFIPLLGETATVSKNQRAQ 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/216 (30%)
		Ion_trans_2	221..295	CDD:285168	26/74 (35%)
		KCNQ_channel	<619..719	CDD:281513
kcnf1a	NP_001076280.1	BTB_2	23..124	CDD:308049
kcnf1a	NP_001076280.1	Ion_trans	184..420	CDD:306908	70/246 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810