Protein Alignment KCNQ and kcnq5a

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_021336521.1
• Gene: kcnq5a / 556841
• ZFINID: ZDB-GENE-090312-185
• Length: 1030
• Species: Danio rerio
• Alignment Length: 1090
• Identity: 352/1090 - (32%)
• Similarity: 478/1090 - (43%)
• Gaps: 342/1090 - (31%)

  Fly    23 GRPNSERILQPRMSLLGKPLNYN-RGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFT 86
            |..|..|....|:|||||||.|: :..||:.|||:||:.|||.|||||. .|..||..||.:||.
Zfish    55 GSENQRRNQGARLSLLGKPLAYSAQSGRRNARYRKLQNYLYNVLERPRA-WAFVYHAFVFTLVFG 118

  Fly    87 CLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCI 151
            ||.|||||||..:.:.:.:.|..:|.::::.|.:|:..|:||:||..||:|..|||:|.::|||:
Zfish   119 CLVLSVFSTIPAHMDLSNHCLLILEFVMIVVFGLEYIIRIWSAGCCCRYRGWQGRLRFARKPFCV 183

  Fly   152 IDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITT 216
            |||:.::|||.|:..|:.|.:|||||||.|||.|||||||||||||||||||||||||.:||:|.
Zfish   184 IDIIVLIASIAVVSAGSQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELVTA 248

  Fly   217 MYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALL 281
            .|||||.|||:|||||:.||:.|.:|:.:|.|||||.|||.|:||||..|.||.|:|:::..|||
Zfish   249 WYIGFLVLIFSSFLVYLVEKEFNKQFATYADALWWGTITLTTIGYGDKTPQTWTGRLLSAGFALL 313

  Fly   282 GISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVA 346
            |||||||||||||||||||||:|.||||..:||.|||:|||.|||.|||||:|||:|||..|..|
Zfish   314 GISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAASLIQCVWRSYAADENSVSIATWKPHLKA 378

  Fly   347 LPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDI 411
            |             |..|     || ::.:.::|.:.|..:         ..|...|||
Zfish   379 L-------------HTCS-----PT-KKDQGESISSKGHSN---------RQRLFRRYT------ 409

  Fly   412 NASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNR 476
                      ....|...||.|                        ..:::|..|...    ::|
Zfish   410 ----------TRKYSQKLSFRE------------------------RVRMASPRGQSV----KSR 436

  Fly   477 DRD-QDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDL 540
            ... .|||..|.....:....||...|          :.|........:|.|::.
Zfish   437 QMSVNDRRSPGTEVAVEGSSPAKVQKS----------WSFNDRTRFRPSLRLKSQ---------- 481

  Fly   541 EAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVANE 605
                     .:.|.:...||               |....|...|.|            .||..|
Zfish   482 ---------SRTTTEADTTL---------------GPDDAFDDKACH------------CDVTVE 510

  Fly   606 EDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLR 670
            :       |:...|..||.||.:|:.||::||||.|:|||||||:|||:|||:|:|.|:|.|..|
Zfish   511 D-------LSAPLKAVIRAIRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTR 568

  Fly   671 LDQILGKQ--GSKAK---------------------------------------------DVYAS 688
            ||.|:|.|  .||||                                             .:|.|
Zfish   569 LDTIVGPQTLSSKAKTFSSPSLHLYYSQAKRKHSAPGLNSAMGPHQTLSTKARNLSSPSLHLYYS 633

  Fly   689 K-------------------------------------ISLASRVVKVERQVADIEEKLDILIKA 716
            :                                     :|:..||.||||||..||.|||.|:..
Zfish   634 QSKKKHAGVDQILGKGQISVDRKGREKILPEGESLEHDMSMLGRVCKVERQVQSIESKLDSLLDI 698

  Fly   717 YMEDRDR-------FLALPL-------PAKPKIHSISPS----------------HKPLHHAHNL 751
            |.:...:       ..||||       ..:..:||...|                |:.||.|  |
Zfish   699 YRQVLQKGSSSMLGLSALPLFELDQTSDYQSSLHSKESSSQLTGSGVSRSCSSNLHRGLHLA--L 761

  Fly   752 AMIDVWKRTAALSVHPEQVTT---TPLLN--PSAPDS----------------------SELRSL 789
            |..::...|.    :|...::   :||||  ||:|||                      |||...
Zfish   762 APSELNLGTG----YPHSASSFSPSPLLNNQPSSPDSFYPSSPPPILTPNNLSRSHQRFSELTRP 822

  Fly   790 TATQTPTTTTDAIATQTPMPPH-----VQHTATNTKSSVLNSYQLGSEKQQHND---------VF 840
            ..|...|:||..:....|.||.     :..|...:::....:..||::.:..:|         |.
Zfish   823 VPTVHSTSTTLQLPPMVPAPPGRPTSLIPETLQESRAECPTNCLLGTQNEVESDKEAESIPSTVQ 887

  Fly   841 MTELENRTKKR-----------------------VTLSLHRSTSEPYSKQEQRITIP-------- 874
            :.:...|..|.                       .:|.:.|...:  |...|.:.:|
Zfish   888 LRDKPERNSKEDGSWRRHLSLDIDPLMLMSSTAAASLQVERGLGK--SLSAQNLMLPTAADCHPA 950

  Fly   875 ----DEGADSLDSSAKPTPPD---SSIILIDEYEDF---EEEDLNCEGEM 914
                ..|:.:.:||.:....|   :.:.:.|:..||   :..|.|...|:
Zfish   951 LSTRSSGSSNNESSDREPLTDWGETELFISDKEMDFLHQQSNDTNFSSEL 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	126/204 (62%)
		Ion_trans_2	221..295	CDD:285168	48/73 (66%)
		KCNQ_channel	<619..719	CDD:281513	59/183 (32%)
kcnq5a	XP_021336521.1	Ion_trans	105..337	CDD:306908	142/231 (61%)
		KCNQ_channel	445..706	CDD:308886	77/323 (24%)
		Herpes_BLLF1	<756..>847	CDD:330317	26/96 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1323
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1321
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24976
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4953
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860