Protein Alignment KCNQ and kcnb2a

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_005163503.1
• Gene: kcnb2a / 555921
• ZFINID: ZDB-GENE-070912-170
• Length: 824
• Species: Danio rerio
• Alignment Length: 638
• Identity: 142/638 - (22%)
• Similarity: 240/638 - (37%)
• Gaps: 186/638 - (29%)

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSV-----FSTIKEY-EEDAVYILFRMEILV 114
            :.:|::.||:|....|  :...:.:..::.:.:|||:     ...|.|: :.:....|..:|.:.
Zfish   175 RQKLWDLLEKPSSSVAAKVLAIISILFIILSTIALSLNTLPELQVIDEFGQSNDNPNLAHVEAVC 239

  Fly   115 VIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG--------- 170
            :.|||||:..|..||.         .:.||.|.|..:||::.||...|.:.:..|.
Zfish   240 IAWFTMEYLLRFLSSP---------NKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNV 295

  Fly   171 ----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLV 231
                |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.||
Zfish   296 RRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLV 352

  Fly   232 YMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGS 295
            :..|||.: .||::...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.:
Zfish   353 FFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVN 417

  Fly   296 GFALKVQQQQRQKHMIRRRQP-----------AATLIQAVWRCY-------------AADEHSVS 336
            .|:...::|:||:..|:||:.           :..|..|..|..             |||.| :|
Zfish   418 NFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARNMELLDVVIEKNEDKAADNH-LS 481

  Fly   337 VATWNIHRVALPSPPASRASSSFKHNTSFVARL----------PTIRRHKSQTIQ------TPGG 385
            .:.||..:    :|.:...|..|......|.:|          |:.:|..:::::      |...
Zfish   482 PSRWNYQK----NPNSELGSKGFDSKYQEVGQLASPERVFRSTPSPQRLNAKSLEQMYNQMTAAS 542

  Fly   386 GDGGGVSKPPGSSRASTRYTRTIRDINASVENLE--VVQNGKSMNPSFSEDSVAETTCLKNIKN- 447
            ...   |..|.:|:.||...|.        |.:|  |||    ..|...|..|.|...|.::.:
Zfish   543 SMS---SSGPSASKVSTVVGRE--------EEMEMKVVQ----CEPRLKEKPVTEIRSLSSVDSF 592

  Fly   448 -------SDASQPATLAN---------------------------------------CKLSSSAG 466
                   |:..:.|.|.|                                       || |..:.
Zfish   593 ASCATDISEVERSALLPNFAGRHPRAPPPLDLSQITSLEKRAKQPTIIKEGLYEFVPCK-SDGSS 656

  Fly   467 SLAQFPDRNRDRDQ-DRRGHGEGEGDQAE---------EQAKAGGSRRNLTIPVVLYGFLHGNFL 521
            :::| .:.|:..|| |.......:|:|.:         |.|:.|.|..:|.:.
Zfish   657 TMSQ-GEENQSFDQSDENVRSPPQGNQVKLKGLKVNFTESAEEGASNLHLVVT------------ 708

  Fly   522 GSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPG 574
             ..::...|:| |.:|..|.||.....            |...:.|..:.|||
Zfish   709 -DDVATLTPKV-PVSDPLLLAGSPRQS------------PRATEGDGATSSPG 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	61/218 (28%)
		Ion_trans_2	221..295	CDD:285168	29/74 (39%)
		KCNQ_channel	<619..719	CDD:281513
kcnb2a	XP_005163503.1	BTB	36..142	CDD:197585
		BTB_2	36..135	CDD:280393
		Ion_trans	229..427	CDD:278921	61/214 (29%)
		Ion_trans_2	340..421	CDD:285168	30/80 (38%)
		Kv2channel	473..695	CDD:281514	45/243 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810