Protein Alignment KCNQ and Shab

DIOPT Version :10

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 1056
• Identity: 213/1056 - (20%)
• Similarity: 349/1056 - (33%)
• Gaps: 352/1056 - (33%)

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYE-------EDAVYILFRMEIL 113
            |..|:..||:|....|  :...:.:..:|.:.:||:: :|:.:.:       :|... |..:|.:
  Fly   448 QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQ-LAMVEAV 510

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||:|:..|..:|.         .:.||.|....|||::.||...|.|.:..:.
  Fly   511 CITWFTLEYILRFSASP---------DKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQ 566

  Fly   171 ------QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASF 229
                  |||        |..:|||::::.|.....:.||..:....:||...|....:|::..|.
  Fly   567 DVRRVVQVF--------RIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS 623

  Fly   230 LVYMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL 293
            |.|..|||..| ||.:..:..||..||:.||||||:.|.|..||:|.:.|.:.|:...|||..|:
  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688

  Fly   294 GSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASS- 357
            .:.||...:.|.|::..::||:             |.|.                   |.|..|
  Fly   689 VNNFAEFYKNQMRREKALKRRE-------------ALDR-------------------AKREGSI 721

  Fly   358 -SFKH---NTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDI-NASVEN 417
             ||.|   ..:|...:..|    ...:.|   |....|..|.|..:::....|...|: :|...|
  Fly   722 VSFHHINLKDAFAKSMDLI----DVIVDT---GKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779

  Fly   418 LEVVQNGKSMNPSFS--EDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQ 480
            |.......:...|.|  ..:...|.|.||.     ...|.|.|..|.:..||         ..:|
  Fly   780 LSQTDGNSTEGESTSGRNPATTGTGCYKNY-----DHVANLRNSNLHNRRGS---------SSEQ 830

  Fly   481 DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
            |                         .:|              ..|..||.....:...:|:.|.
  Fly   831 D-------------------------AVP--------------PYSFDNPNARQTSMMAMESYRR 856

  Fly   546 EDEVHKDTCQRSNTLPLPVK------PDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVAN 604
            |.:......|:.....|.::      |:...|:.|.|........|:....|..::.....:.:|
  Fly   857 EQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNASN 921

  Fly   605 E------------------EDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVME 651
            .                  :|:    .|:......|:.:               :.|.:|.::..
  Fly   922 TAPGSEGAEGGGDGDGGGVDDD----NLSQAKGLPIQMM---------------ITPGEVAELRR 967

  Fly   652 QYAAGHVDLLGRVKMLHLRLDQILG-----------KQGSKAKDV-------YASKISLASRVVK 698
            |.|   ::.|...:|.:|..|..:.           |:.:.|:.|       :...|.|..|:..
  Fly   968 QVA---LENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAA 1029

  Fly   699 VERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAAL 763
            ..||..           ||      .|..||||     .:.|.|.||               .||
  Fly  1030 AGRQAG-----------AY------GLLSPLPA-----PLPPLHGPL---------------LAL 1057

  Fly   764 SVHPEQVTTT--PLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNS 826
            ...|....|:  .:|.|:...||.    |::...|||:..||  .|:...:::.||...||..|
  Fly  1058 PPPPPLPPTSCAAVLLPAISQSSS----TSSSYGTTTSTTIA--LPLDVSLRYGATICSSSNFN- 1115

  Fly   827 YQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSL---------- 881
                     ||                          |:......|:...|..:|
  Fly  1116 ---------HN--------------------------YNNNFNTTTVGGGGNGTLLFGGNYNGSN 1145

  Fly   882 DSSAKPTPPDSSIILIDEY---------------EDFEEEDLNCEGEMDH--------------- 916
            :::|.....|||    |.|               .||.:|....:.:||:
  Fly  1146 NNNADLASVDSS----DTYASCQTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGIS 1206

  Fly   917 --------FPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATR--TAIVITPISPVSSAHN 971
                    .|:  .:|..|....|...|.|       ||||...|..  .|..::|::.|..:.:
  Fly  1207 SSTGFIVGLPS--TNSSGGPRAQVKKSASG-------DTALRNLAAGGVGAGGLSPLNDVYQSFD 1262

  Fly   972 LQQLNDQTTTLNKSNL 987
            :|:...: .:||::::
  Fly  1263 VQERGSR-VSLNENSV 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	72..305	CDD:459842	70/256 (27%)
		KCNQ_channel	<619..719	CDD:460954	19/117 (16%)
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720
		Ion_trans	464..700	CDD:459842	69/254 (27%)