DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and Shab

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	213/1056 - (20%)
Similarity:	349/1056 - (33%)	Gaps:	352/1056 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYE-------EDAVYILFRMEIL 113
            |..|:..||:|....|  :...:.:..:|.:.:||:: :|:.:.:       :|... |..:|.:
  Fly   448 QKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTL-NTLPQLQHIDNGTPQDNPQ-LAMVEAV 510

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||:|:..|..:|.         .:.||.|....|||::.||...|.|.:..:.
  Fly   511 CITWFTLEYILRFSASP---------DKWKFFKGGLNIIDLLAILPYFVSLFLLETNKNATDQFQ 566

  Fly   171 ------QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASF 229
                  |||        |..:|||::::.|.....:.||..:....:||...|....:|::..|.
  Fly   567 DVRRVVQVF--------RIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSS 623

  Fly   230 LVYMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL 293
            |.|..|||..| ||.:..:..||..||:.||||||:.|.|..||:|.:.|.:.|:...|||..|:
  Fly   624 LAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPII 688

  Fly   294 GSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASS- 357
            .:.||...:.|.|::..::||:             |.|.                   |.|..|
  Fly   689 VNNFAEFYKNQMRREKALKRRE-------------ALDR-------------------AKREGSI 721

  Fly   358 -SFKH---NTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDI-NASVEN 417
             ||.|   ..:|...:..|    ...:.|   |....|..|.|..:::....|...|: :|...|
  Fly   722 VSFHHINLKDAFAKSMDLI----DVIVDT---GKQTNVVHPKGKRQSTPNIGRQTLDVQSAPGHN 779

  Fly   418 LEVVQNGKSMNPSFS--EDSVAETTCLKNIKNSDASQPATLANCKLSSSAGSLAQFPDRNRDRDQ 480
            |.......:...|.|  ..:...|.|.||.     ...|.|.|..|.:..||         ..:|
  Fly   780 LSQTDGNSTEGESTSGRNPATTGTGCYKNY-----DHVANLRNSNLHNRRGS---------SSEQ 830

  Fly   481 DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLRNPRVAPANDRDLEAGRD 545
            |                         .:|              ..|..||.....:...:|:.|.
  Fly   831 D-------------------------AVP--------------PYSFDNPNARQTSMMAMESYRR 856

  Fly   546 EDEVHKDTCQRSNTLPLPVK------PDSPSGSPGSGRTGRFFAAASHFLETGFSSPNPIIDVAN 604
            |.:......|:.....|.::      |:...|:.|.|........|:....|..::.....:.:|
  Fly   857 EQQALLQQQQQQQQQMLQMQQIQQKAPNGNGGATGGGVANNLAMVAASSAATAVATATNASNASN 921

  Fly   605 E------------------EDEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVME 651
            .                  :|:    .|:......|:.:               :.|.:|.::..
  Fly   922 TAPGSEGAEGGGDGDGGGVDDD----NLSQAKGLPIQMM---------------ITPGEVAELRR 967

  Fly   652 QYAAGHVDLLGRVKMLHLRLDQILG-----------KQGSKAKDV-------YASKISLASRVVK 698
            |.|   ::.|...:|.:|..|..:.           |:.:.|:.|       :...|.|..|:..
  Fly   968 QVA---LENLQNQRMDNLEQDVPVEFECCFCTTKDFKEFTDAEGVISLPTSDFHKPICLEMRLAA 1029

  Fly   699 VERQVADIEEKLDILIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAAL 763
            ..||..           ||      .|..||||     .:.|.|.||               .||
  Fly  1030 AGRQAG-----------AY------GLLSPLPA-----PLPPLHGPL---------------LAL 1057

  Fly   764 SVHPEQVTTT--PLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNS 826
            ...|....|:  .:|.|:...||.    |::...|||:..||  .|:...:::.||...||..|
  Fly  1058 PPPPPLPPTSCAAVLLPAISQSSS----TSSSYGTTTSTTIA--LPLDVSLRYGATICSSSNFN- 1115

  Fly   827 YQLGSEKQQHNDVFMTELENRTKKRVTLSLHRSTSEPYSKQEQRITIPDEGADSL---------- 881
                     ||                          |:......|:...|..:|
  Fly  1116 ---------HN--------------------------YNNNFNTTTVGGGGNGTLLFGGNYNGSN 1145

  Fly   882 DSSAKPTPPDSSIILIDEY---------------EDFEEEDLNCEGEMDH--------------- 916
            :::|.....|||    |.|               .||.:|....:.:||:
  Fly  1146 NNNADLASVDSS----DTYASCQTHPFLSQGDLTADFNDEACALDIDMDNLYINPLEREQHQGIS 1206

  Fly   917 --------FPTWEIDSDIGVEVDVDADADGDCDESTEDTALLQCATR--TAIVITPISPVSSAHN 971
                    .|:  .:|..|....|...|.|       ||||...|..  .|..::|::.|..:.:
  Fly  1207 SSTGFIVGLPS--TNSSGGPRAQVKKSASG-------DTALRNLAAGGVGAGGLSPLNDVYQSFD 1262

  Fly   972 LQQLNDQTTTLNKSNL 987
            :|:...: .:||::::
  Fly  1263 VQERGSR-VSLNENSV 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	65/226 (29%)
		Ion_trans_2	221..295	CDD:285168	31/74 (42%)
		KCNQ_channel	<619..719	CDD:281513	19/117 (16%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585
		BTB_2	309..408	CDD:280393
		Ion_trans	501..700	CDD:278921	64/216 (30%)
		Ion_trans_2	613..696	CDD:285168	33/82 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910