DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNS3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001269357.1	Gene:	KCNS3 / 3790	HGNCID:	6302	Length:	491	Species:	Homo sapiens

Alignment Length:	346	Identity:	93/346 - (26%)
Similarity:	153/346 - (44%)	Gaps:	66/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCL--------ALSVFSTIKEYEEDAVY--- 105
            :|:.:|:.:::..:|.|.      |.:...|:..:.|        |:.|.|..:...||...
Human   162 LRFGQLRKKIWIRMENPA------YCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDP 220

  Fly   106 ILFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTS- 169
            :|..:||..:.|||.|...||.::.|:.         ||.|.|..|||.|:|:.....|.:.|.
Human   221 VLEGVEIACIAWFTGELAVRLAAAPCQK---------KFWKNPLNIIDFVSIIPFYATLAVDTKE 276

  Fly   170 ---------GQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLI 225
                     |:|  ...||.:|.|:||::.|  ...|...|..::.:::.:..:..:::. :|:.
Human   277 EESEDIENMGKV--VQILRLMRIFRILKLAR--HSVGLRSLGATLRHSYHEVGLLLLFLS-VGIS 336

  Fly   226 FASFLVYMWEKDVNDKFSNFAQ---ALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFA 287
            ..|.|:|..|||  |..|:...   ..||..|::.||||||..|:|..||||||.|.:.||...|
Human   337 IFSVLIYSVEKD--DHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVA 399

  Fly   288 LPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRC-----------YAADEHSVSVATWN 341
            ||..|:.:.|: |..|:|:...:.:..:.|..      :|           ||...|:...:..:
Human   400 LPITIIFNKFS-KYYQKQKDIDVDQCSEDAPE------KCHELPYFNIRDIYAQRMHTFITSLSS 457

  Fly   342 IHRVALPSPPASRASSSFKHN 362
            :..|.  |.|.|..:||.:.|
Human   458 VGIVV--SDPDSTDASSIEDN 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	70/220 (32%)
		Ion_trans_2	221..295	CDD:285168	33/76 (43%)
		KCNQ_channel	<619..719	CDD:281513
KCNS3	NP_001269357.1	BTB_2	17..116	CDD:280393
		BTB	44..122	CDD:197585
		Ion_trans	219..417	CDD:278921	68/214 (32%)
		Ion_trans_2	329..411	CDD:285168	34/85 (40%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810