DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNS2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_065748.1	Gene:	KCNS2 / 3788	HGNCID:	6301	Length:	477	Species:	Homo sapiens

Alignment Length:	336	Identity:	85/336 - (25%)
Similarity:	145/336 - (43%)	Gaps:	75/336 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYE--- 100
            |:||    |..|...:..|.:..|:.|.|       .:.::..|:|...:.....:::.:::
Human   163 GQPL----GNFRRQLWLALDNPGYSVLSR-------VFSILSILVVMGSIITMCLNSLPDFQIPD 216

  Fly   101 ------EDAVYILFRMEILV---VIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDI-- 154
                  ||.     |.||:.   :.|||.|..|         |:......|||.|....:||:
Human   217 SQGNPGEDP-----RFEIVEHFGIAWFTFELVA---------RFAVAPDFLKFFKNALNLIDLMS 267

  Fly   155 -----VTILASIVV------LGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYA 208
                 :|::.::||      ..:|...||     ||.:|.|:||::.|  ...|...|..::.|:
Human   268 IVPFYITLVVNLVVESTPTLANLGRVAQV-----LRLMRIFRILKLAR--HSTGLRSLGATLKYS 325

  Fly   209 HRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKL 273
            :::..:..:|:. :|:...|.:.|..||:.|:..:......||..:::.||||||:||.|..|||
Human   326 YKEVGLLLLYLS-VGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKL 389

  Fly   274 IASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAAD----EHS 334
            .||.|.|.||....||..::.:.|:          |..||::   .|..|:..|...|    ..|
Human   390 TASACILAGILVVVLPITLIFNKFS----------HFYRRQK---QLESAMRSCDFGDGMKEVPS 441

  Fly   335 VSVATWNIHRV 345
            |::..:..|:|
Human   442 VNLRDYYAHKV 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	63/229 (28%)
		Ion_trans_2	221..295	CDD:285168	28/73 (38%)
		KCNQ_channel	<619..719	CDD:281513
KCNS2	NP_065748.1	BTB_2	19..118	CDD:308049
		Ion_trans	186..421	CDD:306908	69/273 (25%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	374..379		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900