Protein Alignment KCNQ and KCNS1

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_016883335.1
• Gene: KCNS1 / 3787
• HGNCID: 6300
• Length: 527
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 94/368 - (25%)
• Similarity: 151/368 - (41%)
• Gaps: 89/368 - (24%)

  Fly     7 IYAFYDIRGYKG-------KCRPGRPNSERILQPR---------MSLLGKPLNYNRGTRRDVRY- 54
            ::||.....|.|       .|...|....|:.||.         .|:...|...:...|...||
Human   132 VFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYG 196

  Fly    55 ----RRLQSRLYNFLERP-RGLHAIFYHVMVFLMVFTCLALSVFSTIKEYE-------------- 100
                .||:.||:..:|.| ..|.:..:..:...:|...:|.....::.||:
Human   197 AARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAG 261

  Fly   101 -------EDAVYILFRMEILVVIWFTMEFGAR-LWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTI 157
                   :|.|  |.|:|...:.||:.|..:| |.:...|:          |...|..:||||::
Human   262 RSPEGVRDDPV--LRRLEYFCIAWFSFEVSSRLLLAPSTRN----------FFCHPLNLIDIVSV 314

  Fly   158 LASIVVL----GMGTSG-----------QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVY 207
            |...:.|    .:|..|           |||     |.:|.|::|::.|  ...|...|..::.:
Human   315 LPFYLTLLAGVALGDQGGKEFGHLGKVVQVF-----RLMRIFRVLKLAR--HSTGLRSLGATLKH 372

  Fly   208 AHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGK 272
            ::|:..|..:|:. :|:...|.:.|..||:.:..|:......|||.:::.||||||:||:|..||
Human   373 SYREVGILLLYLA-VGVSVFSGVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGK 436

  Fly   273 LIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQ 315
            |.||.|.|.||...|||..|:.:.|:          |..||::
Human   437 LAASGCILGGILVVALPITIIFNKFS----------HFYRRQK 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	66/241 (27%)
		Ion_trans_2	221..295	CDD:285168	31/73 (42%)
		KCNQ_channel	<619..719	CDD:281513
KCNS1	XP_016883335.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900