DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and KCNQ2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens

Alignment Length:	1014	Identity:	336/1014 - (33%)
Similarity:	467/1014 - (46%)	Gaps:	288/1014 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PGRPNSER---IL------QPRMSLLGKPLNYNRGT----RRDVRYRRLQSRLYNFLERPRGLHA 73
            ||.|:|.|   :|      ..|.|:|.||.....|.    :|:..||:||:.|||.|||||| .|
Human    29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRG-WA 92

  Fly    74 IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYILFRMEILVVIWFTMEFGARLWSSGCRSRYQGC 138
            ..||..|||:||:||.|||||||||||:.:...|:.:||:.::.|.:|:..|:|::||..||:|.
Human    93 FIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGW 157

  Fly   139 LGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLG 203
            .|||||.::|||:|||:.::|||.||..|:.|.||||||||.|||.|||||:|||||||||||||
Human   158 RGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLG 222

  Fly   204 SVVYAHRQELITTMYIGFLGLIFASFLVYMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPIT 268
            ||||||.:||:|..|||||.||.||||||:.||..||.|..:|.|||||:|||.|:||||..|.|
Human   223 SVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQT 287

  Fly   269 WQGKLIASCCALLGISFFALPAGILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEH 333
            |.|:|:|:...|:|:|||||||||||||||||||:|.||||..:||.|||.|||:.||.||.
Human   288 WNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYAT--- 349

  Fly   334 SVSVATWNIHRVALPSPPASRASSSFKHNT-SFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGS 397
                   |:.|..|             |:| .:..|..|:..:.||| ||.|.
Human   350 -------NLSRTDL-------------HSTWQYYERTVTVPMYSSQT-QTYGA------------ 381

  Fly   398 SRASTRYTRTIRDINASVENLEVVQNGKSMNP-SFSEDSVAETTCLKNIKNSDASQPATLANCKL 461
                   :|.|..:|    .||:::|.||.:. :|.:|...|.:         .||..:|.:...
Human   382 -------SRLIPPLN----QLELLRNLKSKSGLAFRKDPPPEPS---------PSQKVSLKDRVF 426

  Fly   462 SSSAGSLAQFPDRNRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLS 526
            ||..|                            ..||..||.:..|:
Human   427 SSPRG----------------------------VAAKGKGSPQAQTV------------------ 445

  Fly   527 LRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGSPGSGRTGRFFAAASHFLET 591
                |.:|:.|:.||                         ||||..|.|...|....|...|...
Human   446 ----RRSPSADQSLE-------------------------DSPSKVPKSWSFGDRSRARQAFRIK 481

  Fly   592 GFSSPN-------PIIDVANEEDEPRC----TQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYD 645
            |.:|..       |..|:.:::..| |    ..||...|.:||.:..:::.|::|||||:|:|||
Human   482 GAASRQNSEEASLPGEDIVDDKSCP-CEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYD 545

  Fly   646 VKDVMEQYAAGHVDLLGRVKMLHLRLDQILG----------KQGSKAKDV-------YASKI--- 690
            |.||:|||:|||:|:|.|:|.|..|:|.|:|          |..:|....       |:.::
Human   546 VMDVIEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRHKKYPTKGPTAPPRESPQYSPRVDQI 610

  Fly   691 -------------------------SLASRVVKVERQVADIEEKLDILIKAYME-------DRDR 723
                                     |:..|:.|||:||..:|:|||.|:..||:       :.:.
Human   611 VGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEA 675

  Fly   724 FLAL--PLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTTPLLNPSAPDSSEL 786
            :...  |.|| |..|  ||.....|...:..::.:.:.:          ::|...|.|||.::
Human   676 YFGAKEPEPA-PPYH--SPEDSREHVDRHGCIVKIVRSS----------SSTGQKNFSAPPAA-- 725

  Fly   787 RSLTATQTPTTT-------------TDAIA-----TQTPMPPHVQHTATNTKSSVLNSYQLGSEK 833
               ...|.|.:|             |..:.     .:.|.||..:.:        |::|..|:..
Human   726 ---PPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERS--------LSAYGGGNRA 779

  Fly   834 QQHNDVFMTELE---------NRTKKRVTLSLHRSTSEPYSKQEQRITIPD--EGADSLDSSAKP 887
            ...   |:.:.:         |......::|:.....|...:.....:|..  |..|:|:|....
Human   780 SME---FLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAA 841

  Fly   888 TPPDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDI 926
            ..|.:.:           .....|||.|      .|||:
Human   842 VAPCAKV-----------RPYIAEGESD------TDSDL 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	128/204 (63%)
		Ion_trans_2	221..295	CDD:285168	47/73 (64%)
		KCNQ_channel	<619..719	CDD:281513	47/144 (33%)
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	148/231 (64%)
		KCNQ_channel	448..669	CDD:397540	69/246 (28%)
		KCNQ2_u3	684..774	CDD:406935	20/115 (17%)
		KCNQC3-Ank-G_bd	786..886	CDD:403240	16/95 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1392
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	521	1.000	Inparanoid score	I1271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1168835at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40696
orthoMCL	1	0.900	-	-		OOG6_102886
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830