DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNG1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_002228.2	Gene:	KCNG1 / 3755	HGNCID:	6248	Length:	513	Species:	Homo sapiens

Alignment Length:	291	Identity:	88/291 - (30%)
Similarity:	139/291 - (47%)	Gaps:	40/291 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RYRRLQSRLYNFLERPR-GLHA-IFYHVMVFLMVFTCLALSV--FSTIKEYEEDA-----VYILF 108
            |..|...||.:.:|||. ||.. :|..:.|..:..|.:.|||  ..:::|.||..     .:.:|
Human   205 RLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVF 269

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVL--------- 164
            .:|.:.|.||::||..||..:.         .:..|::.|..:||:|.||...:.|
Human   270 IVESVCVGWFSLEFLLRLIQAP---------SKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGR 325

  Fly   165 ---GMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
               |.|.|........||.||..:||.::|:.|.....:.||  :.|.|......:.:.||.:..
Human   326 RKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLG--LTARRCTREFGLLLLFLCVAI 388

  Fly   227 ASF--LVYMWEKDVND--KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFA 287
            |.|  |:|:.|.::.|  :|::.....||.|||:.|||||||||.:..|:::|....|.||...|
Human   389 ALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMA 453

  Fly   288 LPAGILGSGFA---LKVQQQQRQKHMIRRRQ 315
            .|...:...|:   |:::|:| ::.|.||.|
Human   454 FPVTSIFHTFSRSYLELKQEQ-ERVMFRRAQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/228 (29%)
		Ion_trans_2	221..295	CDD:285168	30/77 (39%)
		KCNQ_channel	<619..719	CDD:281513
KCNG1	NP_002228.2	BTB_POZ_KCNG1_2	60..173	CDD:349728
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..204
		Ion_trans	227..471	CDD:395416	73/254 (29%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	424..429		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810