DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCND2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_036413.1	Gene:	KCND2 / 3751	HGNCID:	6238	Length:	630	Species:	Homo sapiens

Alignment Length:	457	Identity:	127/457 - (27%)
Similarity:	192/457 - (42%)	Gaps:	96/457 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QSRLYNFLERPR--GLHAIFYHVMVFLMVFTCLALSVFST---------IKEY---EEDAVYILF 108
            :.|::...|.|.  .:..:||:|..|.:..:.:| :|..|         |||.   |..|| ..|
Human   168 RQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIA-NVVETVPCGSSPGHIKELPCGERYAV-AFF 230

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQVF 173
            .::...|:.||:|:..||  :...|||       :||:....|||:|.||...:.|.|..:..|
Human   231 CLDTACVMIFTVEYLLRL--AAAPSRY-------RFVRSVMSIIDVVAILPYYIGLVMTDNEDV- 285

  Fly   174 ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFLV 231
             :.|...||.|::.|:.:..|.....::||..:.:...||      |||       .:|||:.:.
Human   286 -SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVMF 343

  Fly   232 YMWEKDVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSG 296
            |..:.....||::...|.|:.::|:.|:|||||||.|..||:..|.|:|.|:...|||..::.|.
Human   344 YAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSN 408

  Fly   297 FALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPP---------- 351
            |:....|.||...  ||.|..|.|.    |..||...|.: |.....|..|.|..
Human   409 FSRIYHQNQRADK--RRAQKKARLA----RIRAAKSGSAN-AYMQSKRNGLLSNQLQSSEDEQAF 466

  Fly   352 ASRASSSFK-------H------NTSFV---------ARLPTIRRHKSQTIQTPGGGDGGGVSKP 394
            .|::.|||:       |      |..||         ..:.|:.|..|   .:|......||:
Human   467 VSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSS---HSPSLSSQQGVT-- 526

  Fly   395 PGSSRASTRYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKN--IKNSDASQPATLA 457
              |:..|.|:.:|.|..||:|..        |...|..|.|..:..|::.  :.||.:|..|.:.
Human   527 --STCCSRRHKKTFRIPNANVSG--------SHQGSIQELSTIQIRCVERTPLSNSRSSLNAKME 581

  Fly   458 NC 459
            .|
Human   582 EC 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/211 (32%)
		Ion_trans_2	221..295	CDD:285168	29/80 (36%)
		KCNQ_channel	<619..719	CDD:281513
KCND2	NP_036413.1	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250\|UniProtKB:Q63881	2..20
		Shal-type	3..28	CDD:288455
		BTB_2	43..132	CDD:308049
		Interaction with KCNIP1. /evidence=ECO:0000250\|UniProtKB:Q63881	71..90
		Ion_trans	184..415	CDD:306908	76/249 (31%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	308..321		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	370..375		3/4 (75%)
		DUF3399	445..546	CDD:314709	24/107 (22%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250\|UniProtKB:Q63881, ECO:0000305\|PubMed:16934482	474..630		29/125 (23%)
		Required for dendritic targeting. /evidence=ECO:0000250\|UniProtKB:Q63881	474..489		2/14 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..630
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q63881	627..630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810