Protein Alignment KCNQ and KCND1

DIOPT Version :9

• Sequence 1: NP_788300.3
• Gene: KCNQ / 36071
• FlyBaseID: FBgn0033494
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: XP_024308146.1
• Gene: KCND1 / 3750
• HGNCID: 6237
• Length: 675
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 135/596 - (22%)
• Similarity: 215/596 - (36%)
• Gaps: 179/596 - (30%)

  Fly    57 LQSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTI------------KEYEEDAVYIL 107
            |:.||:...|.|....|  :||:|..|.:..:.:| :|..||            :...|......
Human   168 LRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIA-NVVETIPCRGSARRSSREQPCGERFPQAF 231

  Fly   108 FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSGQV 172
            |.|:...|:.||.|:..||:::..|.|         |::....:||:|.||...:.|.:..:..|
Human   232 FCMDTACVLIFTGEYLLRLFAAPSRCR---------FLRSVMSLIDVVAILPYYIGLLVPKNDDV 287

  Fly   173 FATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFL-------GLIFASFL 230
              :.|...||.|::.|:.:..|.....::||..:.:...||      |||       .:|||:.:
Human   288 --SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASEL------GFLLFSLTMAIIIFATVM 344

  Fly   231 VYMWEKDVN-DKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            .|. ||..| ..|::...|.|:.::|:.|:|||||||.|..||:..|.|:|.|:...|||..::.
Human   345 FYA-EKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIV 408

  Fly   295 SGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSF 359
            |.|:....|.||...  ||.|....|.                      |:.|.....:.|...:
Human   409 SNFSRIYHQNQRADK--RRAQQKVRLA----------------------RIRLAKSGTTNAFLQY 449

  Fly   360 KHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNG 424
            |.|..               ::...|.|..|||.......|.......::|..:..|....|:|.
Human   450 KQNGG---------------LEVGRGLDRVGVSHNGEEGAALIALLHLLQDSGSGEEQALCVRNR 499

  Fly   425 KSMNPSFSE--DSVAETTCLK--------------------NIKNSDASQP----ATLANC---- 459
            .:.......  ..:.:|||.:                    :...|.:|||    :.|::|
Human   500 SAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRR 564

  Fly   460 ------KLSSSAGSLAQFPDRNRDRDQD-----RRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLY 513
                  :|::|..|::    |...::.|     ||.|             |..||.:|....
Human   565 AKRRAIRLANSTASVS----RGSMQELDMLAGLRRSH-------------APQSRSSLNAKP--- 609

  Fly   514 GFLHG---------NFLGSTLSLRNPRVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSP 569
               |.         :|:.:.:|:..|   |||..|                       ..:|.||
Human   610 ---HDSLDLNCDSRDFVAAIISIPTP---PANTPD-----------------------ESQPSSP 645

  Fly   570 SGSPGSGRTGR 580
            .|...:|.|.|
Human   646 GGGGRAGSTLR 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	64/212 (30%)
		Ion_trans_2	221..295	CDD:285168	31/81 (38%)
		KCNQ_channel	<619..719	CDD:281513
KCND1	XP_024308146.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:308049
		Ion_trans	185..417	CDD:306908	71/250 (28%)
		DUF3399	447..578	CDD:314709	23/145 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810