DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNC3

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_004968.2	Gene:	KCNC3 / 3748	HGNCID:	6235	Length:	757	Species:	Homo sapiens

Alignment Length:	392	Identity:	97/392 - (24%)
Similarity:	155/392 - (39%)	Gaps:	112/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRRLQSRLYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEEDAVYI------------ 106
            :||.|.|::...|.|....|..|  :.|..:|..| :|:.:...|..|..::|
Human   269 WRRWQPRVWALFEDPYSSRAARY--VAFASLFFIL-ISITTFCLETHEGFIHISNKTVTQASPIP 330

  Fly   107 -----------------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDI 154
                             |..:|.:.|:|||.||..|:         ..|..:::|:|....|||.
Human   331 GAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRI---------TFCPDKVEFLKSSLNIIDC 386

  Fly   155 VTILASIVVLGM-GTSGQVF--ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITT 216
            |.||...:.:|: |.|.:..  ....||.:||.:|||:.::.|.....::||..:.|...|.:..
Human   387 VAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 451

  Fly   217 MYIGFLGLIFASFLVYMWEK---DVND-------KFSNFAQALWWGVITLCTVGYGDMVPITWQG 271
            :....||::..:.::|..|:   |.:|       .|.|.....||.|:|:.|:|||||.|.||.|
Human   452 IIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSG 516

  Fly   272 KLIASCCALLGISFFALPAGIL----GSGFALKVQQQ----QRQKHMIRRRQPAATLIQAVWRCY 328
            .|:.:.|||.|:...|:|..::    |..::|.:.:|    ::.||:.|..||.:.
Human   517 MLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSP--------- 572

  Fly   329 AADEHSVSVATWNIHRVALPSPPASRASSSFKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSK 393
                        |..:...|.||                  |....|.|           ||:|.
Human   573 ------------NYCKPDPPPPP------------------PPHPHHGS-----------GGISP 596

  Fly   394 PP 395
            ||
Human   597 PP 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/254 (26%)
		Ion_trans_2	221..295	CDD:285168	29/87 (33%)
		KCNQ_channel	<619..719	CDD:281513
KCNC3	NP_004968.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		Important for normal N-type inactivation. /evidence=ECO:0000269\|PubMed:26997484	1..78
		Potassium_chann	1..>18	CDD:314363
		BTB_KCNC1_3	89..202	CDD:349721
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..232
		Ion_trans	289..550	CDD:366146	72/272 (26%)
		Selectivity filter. /evidence=ECO:0000250	503..508		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..613		17/93 (18%)
		PHA03247	<637..752	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810