DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNC2

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_631875.1	Gene:	KCNC2 / 3747	HGNCID:	6234	Length:	638	Species:	Homo sapiens

Alignment Length:	487	Identity:	118/487 - (24%)
Similarity:	190/487 - (39%)	Gaps:	140/487 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DIYAFYDIRGYKGKCRPGRP-NSERILQPRMSL-----LGKPLNYNRGTRRDVRYRRLQSRLYNF 64
            ||:...|:.|       |.| :.|.:...|:.:     ||.|      ..:..|:||||.|::..
Human   167 DIFETPDLIG-------GDPGDDEDLAAKRLGIEDAAGLGGP------DGKSGRWRRLQPRMWAL 218

  Fly    65 LERP---RGLHAIFYHVMVFLMVFT---CL---------------ALSVFSTIKEYEEDAVYILF 108
            .|.|   |....|.:..:.|::|..   ||               .::..|.:.:||.:....|.
Human   219 FEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALT 283

  Fly   109 RMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM-GTSGQV 172
            .:|.:.|:|||.||..|:..|.         .:|:|:|....|||.|.||...:.:|: |.|.:.
Human   284 YVEGVCVVWFTFEFLVRIVFSP---------NKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKA 339

  Fly   173 F--ATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE 235
            .  ....||.:||.:|||:.::.|.....::||..:.|...|.:..:....||::..:.::|..|
Human   340 AKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAE 404

  Fly   236 K---DVND-------KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            :   ..||       :|.|.....||.|:|:.|:|||||.|.||.|.|:.:.|||.|:...|:|.
Human   405 RVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPV 469

  Fly   291 GILGSGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRA 355
            .::.:.|.:.......::.:.|:|:                :|               .|||.:|
Human   470 PVIVNNFGMYYSLAMAKQKLPRKRK----------------KH---------------IPPAPQA 503

  Fly   356 SSS--------------------------FKHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKP 394
            ||.                          .:||.|.::                  ||....|:|
Human   504 SSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLS------------------GDDSTGSEP 550

  Fly   395 PGS--SRASTRYTRTIRDINASVENLEVVQNG 424
            |.|  .|...|.:.| ||.|...|...::..|
Human   551 PLSPPERLPIRRSST-RDKNRRGETCFLLTTG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	65/217 (30%)
		Ion_trans_2	221..295	CDD:285168	29/83 (35%)
		KCNQ_channel	<619..719	CDD:281513
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..93
		Ion_trans	228..484	CDD:395416	72/264 (27%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..572		13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810