DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KCNQ and KCNC1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001106212.1	Gene:	KCNC1 / 3746	HGNCID:	6233	Length:	585	Species:	Homo sapiens

Alignment Length:	343	Identity:	89/343 - (25%)
Similarity:	149/343 - (43%)	Gaps:	70/343 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GRPNSERILQPRMSLL----GKPLNYNRGTRRDVRYRRLQSRLYNFLERPRG-------LHAIFY 76
            |....|..:..|::|.    |:|..:         :||.|.|::...|.|..       ..|..:
Human   143 GDGEDELEMTKRLALSDSPDGRPGGF---------WRRWQPRIWALFEDPYSSRYARYVAFASLF 198

  Fly    77 HVMVFLMVFTCLALSVFSTI------------------KEYEEDAVYILFRMEILVVIWFTMEFG 123
            .::|.:..|.......|:.|                  :|.|.:|  .|..:|.:.|:|||.||.
Human   199 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEA--FLTYIEGVCVVWFTFEFL 261

  Fly   124 ARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM-GTSGQVF--ATSALRGLRFFQ 185
            .|:..         |..:::|:|....|||.|.||...:.:|: |.|.:..  ....||.:||.:
Human   262 MRVIF---------CPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVR 317

  Fly   186 ILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEK---DVND------- 240
            |||:.::.|.....::||..:.|...|.:..:....||::..:.::|..|:   ..||
Human   318 ILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHT 382

  Fly   241 KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGIL----GSGFALKV 301
            .|.|.....||.|:|:.|:|||||.|.||.|.|:.:.|||.|:...|:|..::    |..::|.:
Human   383 HFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447

  Fly   302 QQQ----QRQKHMIRRRQ 315
            .:|    :::||:.|..|
Human   448 AKQKLPKKKKKHIPRPPQ 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	67/225 (30%)
		Ion_trans_2	221..295	CDD:285168	29/87 (33%)
		KCNQ_channel	<619..719	CDD:281513
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..147		1/3 (33%)
		Ion_trans	189..447	CDD:395416	72/268 (27%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810