DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and KCNB1

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_004966.1	Gene:	KCNB1 / 3745	HGNCID:	6231	Length:	858	Species:	Homo sapiens

Alignment Length:	755	Identity:	159/755 - (21%)
Similarity:	270/755 - (35%)	Gaps:	201/755 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QSRLYNFLERPRGLHA--IFYHVMVFLMVFTCLALSVFSTIKEYEEDAVY-------ILFRMEIL 113
            :.:|::.||:|....|  |...:.:..:|.:.:|||: :|:.|.:....:       .|..:|.:
Human   172 RKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSL-NTLPELQSLDEFGQSTDNPQLAHVEAV 235

  Fly   114 VVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGMGTSG-------- 170
            .:.|||||:..|..||.         .:.||.|.|...||::.||...|.:.:..|.
Human   236 CIAWFTMEYLLRFLSSP---------KKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQN 291

  Fly   171 -----QVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFL 230
                 |:|        |..:|||::::.|.....:.||..:.....||...:....:|::..|.|
Human   292 VRRVVQIF--------RIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSL 348

  Fly   231 VYMWEKDVND-KFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILG 294
            |:..|||.:| ||.:...:.||..||:.||||||:.|.|..||::...|.:.|:...|||..|:.
Human   349 VFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413

  Fly   295 SGFALKVQQQQRQKHMIRRRQPAATLIQAVWRCYAADEHSVSVATWNIHRVALPSPPASRASSSF 359
            :.|:...::|:||:..|:||:                                       |....
Human   414 NNFSEFYKEQKRQEKAIKRRE---------------------------------------ALERA 439

  Fly   360 KHNTSFVARLPTIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQNG 424
            |.|.|.|                              |......:.|:|..::..||     :||
Human   440 KRNGSIV------------------------------SMNMKDAFARSIEMMDIVVE-----KNG 469

  Fly   425 KSM-----------NPS---FSEDSVAETTCLKNIKNSDASQPATLANCKLSSSAG----SLAQF 471
            ::|           :|:   :::.:::||:..|:.:..:...|.     |..||:.    ::.|.
Human   470 ENMGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSPE-----KARSSSSPQHLNVQQL 529

  Fly   472 PDR-NRDRDQDRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSLR-----NP 530
            .|. |:......:.....:...|:.:.|......::..||            :.|..|     :.
Human   530 EDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPV------------APLPTRTEGVIDM 582

  Fly   531 RVAPANDRDLEAGRDEDEVHKDTCQRSNTLPLPVKPDSPSGS--PGSGRTGRFFAAASHFLETGF 593
            |...:.|..:....|..|     ..|.:..||...|....||  |..|..|...|:...|:|.
Human   583 RSMSSIDSFISCATDFPE-----ATRFSHSPLTSLPSKTGGSTAPEVGWRGALGASGGRFVEA-- 640

  Fly   594 SSPNPIIDVANEE----DEPRCTQLTNRHKTAIRFIRKLKYFVARRKFKEALKPYDVKDVMEQYA 654
               ||..|.:...    :.|:.:..||         ..||....:..|.|. .|..:..|:..|
Human   641 ---NPSPDASQHSSFFIESPKSSMKTN---------NPLKLRALKVNFMEG-DPSPLLPVLGMY- 691

  Fly   655 AGHVDLLGR----VKMLHLRLDQILGKQGSKAKDVYASKISLASRVVKVERQVA---DIEEKLDI 712
              |..|..|    ..:..|....:|.|.....:....:..|..:.....|:..|   :.|..:..
Human   692 --HDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQ 754

  Fly   713 LIKAYMEDRDRFL---------ALPLPAKPKIHSISPSHK 743
            .|.|..:|..:.|         :||....||..:.:.|.|
Human   755 YIDADTDDEGQLLYSVDSSPPKSLPGSTSPKFSTGTRSEK 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/225 (28%)
		Ion_trans_2	221..295	CDD:285168	30/74 (41%)
		KCNQ_channel	<619..719	CDD:281513	19/106 (18%)
KCNB1	NP_004966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	59..75
		Ion_trans	188..424	CDD:395416	69/253 (27%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250\|UniProtKB:P15387	448..481		7/37 (19%)
		Kv2channel	467..679	CDD:397541	45/247 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..524		9/57 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..574		5/47 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..807		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810