DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNQ and KCNA10

DIOPT Version :9

Sequence 1:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_005540.1	Gene:	KCNA10 / 3744	HGNCID:	6219	Length:	511	Species:	Homo sapiens

Alignment Length:	267	Identity:	70/267 - (26%)
Similarity:	120/267 - (44%)	Gaps:	41/267 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LYNFLERPRGLHAIFYHVMVFLMVFTCLALSVFSTIKEYEED-------------AVYIL----- 107
            |:.:.|......|:  .|:..|:|...:.:....|:.|:.||             :..:|
Human   205 LFEYPESSSAARAV--AVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMF 267

  Fly   108 ----FRMEILVVIWFTMEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIV-------TILASI 161
                |.:|...::|||.|...         |:..|..:..|.:....||||:       |::..:
Human   268 TDPFFMVESTCIVWFTFELVL---------RFVVCPSKTDFFRNIMNIIDIISIIPYFATLITEL 323

  Fly   162 VVLGMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIF 226
            |.....::.|..:.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..|:|:|.
Human   324 VQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVIL 388

  Fly   227 ASFLVYMWEKDVNDK-FSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPA 290
            .|..||..|.|..:. ||:.....||.|:|:.|||||||.|.|..||::.:.||:.|:...|||.
Human   389 FSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPV 453

  Fly   291 GILGSGF 297
            .::.|.|
Human   454 PVIVSNF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	62/228 (27%)
		Ion_trans_2	221..295	CDD:285168	31/74 (42%)
		KCNQ_channel	<619..719	CDD:281513
KCNA10	NP_005540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..50
		BTB_2	88..179	CDD:308049
		Ion_trans	255..467	CDD:306908	60/215 (28%)
		Selectivity filter. /evidence=ECO:0000250	421..426		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810